A case of anti-TIF1-γ-positive amyopathic dermatomyositis associated with gastric cancer

Tomoyo Matsuda, Keiko Sakamoto, Yuko Haraguchi, Satoko Shibata-Kikuchi, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

抄録

A 63-year-old Japanese male visited our hospital complaining of a 3-month history of erythema on his chest and back. Initial physical examinations revealed pruritic erythema on his cheek, V-neck area, posterior neck, and shoulders with Gottron's sign and nailfold telangiectasia. He had no muscle pain or weakness. Histopathologically, an interface change was evident with lymphocytic infiltration. Laboratory examinations showed positivity for anti-transcriptional intermediary factor (TIF)1-γ antibody, but other data were negative or within normal ranges including anti-Mi-2 antibody, anti-Jo-1 antibody, KL-6, creatine phosphokinase, and aldolase. Radiographic examinations showed no pulmonary abnormality. He was finally diagnosed as having amyopathic dermatomyositis. Because of a frequent association between malignancies and positivity for anti-TIF1-γ antibody, further extensive examinations were carried out and early gastric cancer was discovered. After starting the systemic administration of prednisolone (30 mg/day), his gastric cancer was removed successfully and the cutaneous lesions were subsequently completely cured. The systemic steroid treatment was tapered and terminated without any recurrence of amyopathic dermatomyositis. Anti-TIF1-γ antibody also became undetectable.

元の言語英語
ページ(範囲)9-13
ページ数5
ジャーナルNishinihon Journal of Dermatology
81
発行部数1
DOI
出版物ステータス出版済み - 1 1 2019

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Stomach Neoplasms
Erythema
Anti-Idiotypic Antibodies
Neck
Telangiectasis
Fructose-Bisphosphate Aldolase
Cheek
Myalgia
Muscle Weakness
Creatine Kinase
Prednisolone
Physical Examination
Reference Values
Thorax
Steroids
Recurrence
Lung
Skin
Antibodies
transcriptional intermediary factor 1

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

A case of anti-TIF1-γ-positive amyopathic dermatomyositis associated with gastric cancer. / Matsuda, Tomoyo; Sakamoto, Keiko; Haraguchi, Yuko; Shibata-Kikuchi, Satoko; Furue, Masutaka.

:: Nishinihon Journal of Dermatology, 巻 81, 番号 1, 01.01.2019, p. 9-13.

研究成果: ジャーナルへの寄稿記事

Matsuda, Tomoyo ; Sakamoto, Keiko ; Haraguchi, Yuko ; Shibata-Kikuchi, Satoko ; Furue, Masutaka. / A case of anti-TIF1-γ-positive amyopathic dermatomyositis associated with gastric cancer. :: Nishinihon Journal of Dermatology. 2019 ; 巻 81, 番号 1. pp. 9-13.
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