A case of CD30-positive adult T-cell leukemia/lymphoma presenting spontaneous regression and recurrence of skin lesions

Yumiko Kaku, Monji Koga, Shinichi Imafuku, Juichiro Nakayama, Kaori Koga, Noriyuki Sakata, Masutaka Furue

研究成果: ジャーナルへの寄稿記事


A 79-year-old woman presented with recurring reddish nodules on her extremities. Several nodules had been appearing, and disappearing spontaneously within a few months without any medications on her body and extremities. She visited our hospital with a reddish nodule on her left wrist in January 2011. Biopsy and histopathological examination of the lesion revealed dense infiltration of atypical lymphocytes in the epidermis and dermis, which were mostly CD30-positive. We therefore made an initial diagnosis of anaplastic large cell lymphoma. However, laboratory testing revealed serum antibodies to human T-lymphotropic virus type 1 (HTLV-1), and Southern blot analysis of the biopsy specimen demonstrated a monoclonal integration band of the HTLV-1 provirus DNA. Based on these findings, we made the final diagnosis of CD30- positive adult T-cell leukemia/lymphoma (ATLL). After electronic beam radiotherapy, the lesion disappeared completely. According to our literature search, we believe that this case is the first report of ATLL that presented CD30-positive skin tumors that had repeatedly regressed and recurred.

ジャーナルNishinihon Journal of Dermatology
出版物ステータス出版済み - 1 1 2014


All Science Journal Classification (ASJC) codes

  • Dermatology