TY - JOUR
T1 - A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma
T2 - Usefulness of the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome
AU - Kukidome, Daisuke
AU - Miyamura, Nobuhiro
AU - Sakakida, Kourin
AU - Shimoda, Seiya
AU - Shigematu, Yoshinori
AU - Nishi, Kazuhiko
AU - Yamashita, Yasuyuki
AU - Eto, Masatoshi
AU - Sasano, Hironobu
AU - Araki, Eiichi
PY - 2012
Y1 - 2012
N2 - A 36-year-old woman with Cushing syndrome was evaluated for coexisting hyperaldosteronism, which was suggested by an abnormal response of the aldosterone-to-cortisol ratio in peripheral blood to the ACTHadministration despite a low basal aldosterone-to-renin ratio. Computed tomography revealed two independent tumors in the left adrenal gland, and adrenal venous sampling indicated hyperaldosteronism in addition to hypercortisolism in the same side. Postsurgical study including immunohistochemical analysis of steroidogenic enzymes suggested one adenoma to be cortisol-producing and the other, aldosterone-producing. The comorbidity of these different hormone-producing adenomas is not rare and careful pre-surgical evaluation is necessary to avoid post-surgical exacerbation of latent hyperaldosteronism.
AB - A 36-year-old woman with Cushing syndrome was evaluated for coexisting hyperaldosteronism, which was suggested by an abnormal response of the aldosterone-to-cortisol ratio in peripheral blood to the ACTHadministration despite a low basal aldosterone-to-renin ratio. Computed tomography revealed two independent tumors in the left adrenal gland, and adrenal venous sampling indicated hyperaldosteronism in addition to hypercortisolism in the same side. Postsurgical study including immunohistochemical analysis of steroidogenic enzymes suggested one adenoma to be cortisol-producing and the other, aldosterone-producing. The comorbidity of these different hormone-producing adenomas is not rare and careful pre-surgical evaluation is necessary to avoid post-surgical exacerbation of latent hyperaldosteronism.
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U2 - 10.2169/internalmedicine.51.5597
DO - 10.2169/internalmedicine.51.5597
M3 - Article
C2 - 22333376
AN - SCOPUS:84857157533
VL - 51
SP - 395
EP - 400
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 4
ER -