TY - JOUR
T1 - A case of Fanconi's syndrome caused by long-term administration of adefovir by a patient with chronic hepatitis B
AU - Kumade, Eri
AU - Furusyo, Norihiro
AU - Mitsumoto, Fujiko
AU - Ogawa, Eiichi
AU - Toyoda, Kazuhiro
AU - Kainuma, Mosaburo
AU - Masayuki, Murata
AU - Hayashi, Jun
PY - 2013/1/1
Y1 - 2013/1/1
N2 - A 61-year-old Japanese man with chronic hepatitis B complained of pain in both legs after 64 months of adefovir dipivoxil (ADV) administration. He was diagnosed with stress fractures of both lower legs. Blood data showed elevated alkaline phosphatase, decreased uric acid levels in serum, hypophosphatemia, and normal anion gap metabolic acidosis, resulting in a diagnosis of hypophosphatemic osteomalacia secondary to proximal renal tubulopathy: Fanconi's syndrome. This report emphasizes the importance of being alert to the possibility of Fanconi's syndrome in patients treated long-term with ADV and the need for monitoring blood phosphate, alkaline phosphatase, and uric acid in serum.
AB - A 61-year-old Japanese man with chronic hepatitis B complained of pain in both legs after 64 months of adefovir dipivoxil (ADV) administration. He was diagnosed with stress fractures of both lower legs. Blood data showed elevated alkaline phosphatase, decreased uric acid levels in serum, hypophosphatemia, and normal anion gap metabolic acidosis, resulting in a diagnosis of hypophosphatemic osteomalacia secondary to proximal renal tubulopathy: Fanconi's syndrome. This report emphasizes the importance of being alert to the possibility of Fanconi's syndrome in patients treated long-term with ADV and the need for monitoring blood phosphate, alkaline phosphatase, and uric acid in serum.
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U2 - 10.2957/kanzo.54.187
DO - 10.2957/kanzo.54.187
M3 - Article
AN - SCOPUS:84940362817
VL - 54
SP - 187
EP - 193
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
SN - 0451-4203
IS - 3
ER -
