A case of hepatic resection after chemotherapy for metastatic colon cancer of the liver with invasion of the inferior vena cava and hepatic vein

Hisateru Komatsu, Akira Tomokuni, Hiroshi Wada, Shogo Kobayashi, Yoshito Tomimaru, Tadafumi Asaoka, Naoki Hama, Koichi Kawamoto, Shigeru Marubashi, Hidetoshi Eguchi, Koji Umeshita, Yuichiro Doki, Masaki Mori, Hiroaki Nagano

研究成果: Contribution to journalArticle査読

抄録

A 61-year-old man presented with lower abdominal pain. Further examination revealed descending colon cancer and multiple liver metastases (S1, S2, and S5). The largest metastatic lesion in S1 showed massive invasion to the inferior vena cava (IVC) and was considered unresectable. Resection of the primary colon cancer was performed in January 2011, followed by several types of systemic chemotherapy (12 courses of capecitabine plus oxaliplatin [XELOX] +bevacizumab [Response Evaluation Criteria In Solid Tumors {RECIST}: PD], 5 courses of folinic acid, fluorouracil, and irinotecan [FOLFIRI] + bevacizumab [RECIST: SD], and 13 courses of FOLFIRI + panitumumab). After these regimens, the lesions in S1 and S2 substantially decreased in size (RECIST: PR), and the lesion in S5 was no longer visible. The extent of invasion to the IVC significantly reduced, and liver resection (extended left lobectomy) and partial IVC resection were performed in November 2013 without reconstruction of the IVC by using a vascular prosthesis. The patient was discharged uneventfully on postoperative day 16, and administration of tegafur-uracil-Leucovorin (UFT/UZEL) was initiated. After 4 months, a recurrent lesion was found in S5, and partial liver resection was performed. In addition, FOLFIRI+panitumumab was reinitiated for the multiple lung metastases. The patient is alive without progression of disease 3 years and 4 months after colectomy.

本文言語英語
ページ(範囲)2059-2061
ページ数3
ジャーナルJapanese Journal of Cancer and Chemotherapy
41
12
出版ステータス出版済み - 11 2014

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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