[A case of hepatocellular carcinoma with respiratory failure caused by widespread tumor microemboli].

Kosuke Tanaka, Akio Nakasya, Masanori Miyazaki, Shinichiro Takao, Nobito Higuchi, Masatake Tanaka, Yuki Tanaka, Masaki Kato, Kazuhiro Kato, Ryoichi Takayanagi, Shinichi Aishima

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抜粋

A 76-year-old man with hepatocellular carcinoma (HCC) was admitted to our hospital suffering from rapidly progressing dyspnea. Chest computed tomography on admission merely showed ground-glass patterns in both lung fields without thrombi in the pulmonary trunk. On the third day, pulmonary blood flow scintigraphy was performed because of progression of his dyspnea, and showed multiple defects indicating widespread thrombi in the peripheral pulmonary arteries. He died of respiratory failure on day 13. A needle necropsy revealed the presence of multiple foci of adenocarcinoma nests in the lungs, suggesting venous thrombi from the poorly differentiated HCC. Although HCC frequently metastasizes to the lung, patients with lung metastasis rarely result in respiratory failure. It is well known that some patients with adenocarcinoma including HCC can develop respiratory failure owing to pulmonary tumor thrombotic microangiopathy (PTTM). In our case, however, pathological examination showed widespread tumor microemboli in the lung, but no stenosis or fibrocellular intimal proliferation in the small arteries and arterioles, which are essential findings of PTTM. Although we concluded that the respiratory failure in this case was mainly caused by widespread tumor microemboli, it remains unclear why such dissemination rapidly developed.

元の言語英語
ページ(範囲)298-302
ページ数5
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
102
発行部数10
出版物ステータス出版済み - 1 1 2011

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Tanaka, K., Nakasya, A., Miyazaki, M., Takao, S., Higuchi, N., Tanaka, M., ... Aishima, S. (2011). [A case of hepatocellular carcinoma with respiratory failure caused by widespread tumor microemboli]. Fukuoka igaku zasshi = Hukuoka acta medica, 102(10), 298-302.