A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus

Mika Fujihira, Taiki Higashi, Maiko Yokomizo, Keiichirou Takase, Yasuhiro Idewaki, Atsushi Fukunaga, Kunitoshi Sakurai, Hiroshi Toyoshima, Hiroshi Ohtani, Udai Nakamura, Takanari Kitazono, Masanori Iwase

研究成果: ジャーナルへの寄稿記事

抄録

An 80-year-old woman was admitted due to liver dysfunction. She had been treated for type 2 diabetes mellitus by oral anti-diabetic medications. Laboratory examinations findings were as follows: AST 96 IU/L, ALT 134 IU/L, γ -GTP 823 IU/L, fasting serum glucose 204 mg/dL, HbA1c 8.3 %, C-peptide 2.46 ng/mL, anti-GAD antibody 55.8 U/mL, and IgG4 704 mg/dL. Imaging showed marked dilation of bile ducts without swelling of the pancreas or narrowing of the pancreatic ducts. The histological findings of a liver biopsy were compatible with IgG4-related sclerosing cholangitis. Both steroid therapy and insulin therapy were started and led to the amelioration of the liver function and insulin secretion as well as a reduction in anti-GAD antibody. We herein report a case of IgG4-related sclerosing cholangitis associated with diabetes mellitus with positivity for anti-GAD antibody, a situation that is rare to our knowledge.

元の言語英語
ページ(範囲)17-23
ページ数7
ジャーナルJournal of the Japan Diabetes Society
62
発行部数1
DOI
出版物ステータス出版済み - 1 1 2019

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Sclerosing Cholangitis
Anti-Idiotypic Antibodies
Diabetes Mellitus
Immunoglobulin G
Insulin
C-Peptide
Pancreatic Ducts
Liver
Guanosine Triphosphate
Bile Ducts
Type 2 Diabetes Mellitus
Liver Diseases
Dilatation
Pancreas
Fasting
Steroids
Biopsy
Glucose
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus. / Fujihira, Mika; Higashi, Taiki; Yokomizo, Maiko; Takase, Keiichirou; Idewaki, Yasuhiro; Fukunaga, Atsushi; Sakurai, Kunitoshi; Toyoshima, Hiroshi; Ohtani, Hiroshi; Nakamura, Udai; Kitazono, Takanari; Iwase, Masanori.

:: Journal of the Japan Diabetes Society, 巻 62, 番号 1, 01.01.2019, p. 17-23.

研究成果: ジャーナルへの寄稿記事

Fujihira, M, Higashi, T, Yokomizo, M, Takase, K, Idewaki, Y, Fukunaga, A, Sakurai, K, Toyoshima, H, Ohtani, H, Nakamura, U, Kitazono, T & Iwase, M 2019, 'A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus' Journal of the Japan Diabetes Society, 巻. 62, 番号 1, pp. 17-23. https://doi.org/10.11213/tonyobyo.62.17
Fujihira, Mika ; Higashi, Taiki ; Yokomizo, Maiko ; Takase, Keiichirou ; Idewaki, Yasuhiro ; Fukunaga, Atsushi ; Sakurai, Kunitoshi ; Toyoshima, Hiroshi ; Ohtani, Hiroshi ; Nakamura, Udai ; Kitazono, Takanari ; Iwase, Masanori. / A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus. :: Journal of the Japan Diabetes Society. 2019 ; 巻 62, 番号 1. pp. 17-23.
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AU - Idewaki, Yasuhiro

AU - Fukunaga, Atsushi

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