A case of imatinib-resistant GIST treated by sunitinib

Yasuo Sakamoto, Hisafumi Akimoto, Miyako Kojo, Hiroyuki Kawano, Yoshiki Chinen, Kazutoyo Morita, Masahiko Sugiyama, Hiroshi Saeki, Kazuhito Minami, Yuji Soejima, Yoshihisa Sakaguchi, Yasushi Toh, Takeshi Okamura

研究成果: Contribution to journalArticle査読


We report a case of imatinib-resistant GIST, successfully treated by sunitinib. A 62-year-old man with high-grade fever and a huge abdominal tumor was diagnosed with malignant GIST and multiple liver metastases. We performed total gastrectomy combined with distal pancreatectomy, and splenectomy for palliation. Imatinib at a dose of 300 mg/day was administered postoperatively, and the liver metastases was well controlled. After nine months, abdominal dissemination increased, and we raised the dose of imatinib to 400 mg/day for the progressive state. Subsequently, we had to discontinue imatinib due to its adverse effects. Because the tumors progressed greatly while imatinib was discontinued, we changed to sunitinib. After wards, tumors reduced and his general condition improved remarkably. Although tumors progressed after five months, he was able to obtain good QOL during the administration of sunitinib. Sunitinib is useful for imatinib-resistant GIST, and may be a promising treatment even for patients with poor PS.

ジャーナルJapanese Journal of Cancer and Chemotherapy
出版ステータス出版済み - 5 15 2011

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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