A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease

Yoshikazu Hayashi, Masafumi Moriyama, takashi maehara, Yuichi Goto, Shintarou Kawano, Miho Ohta, Akihiko Tanaka, Sachiko Furukawa, Hayashida Jun-Nosuke, Tamotsu Kiyoshima, Mayumi Shimizu, Toru Chikui, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Background: Mantle cell lymphoma (MCL) is a relatively uncommon type of non-Hodgkin lymphoma. It develops in the outer edge of a lymph node called the mantle zone. In contrast, IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by elevated serum IgG4 and persistent bilateral enlargement of lacrimal glands (LGs) and salivary glands (SGs), with infiltration of IgG4-positive plasma cells. Recent studies indicated the importance of differentiation between IgG4-DS and malignant lymphoma. Case presentation: An 82-year-old man was suspected of IgG4-DS because of a high serum IgG level (2174 mg/dL) and bilateral swelling of LGs and SGs. Lip biopsy and fine needle biopsy of submandibular gland were performed, and subsequently, MCL was diagnosed through the histopathological findings. Conclusions: MCL most commonly occurs in the Waldeyer ring, but rarely in the stomach, spleen, skin, LG, and SG. We report an unusual case of MCL involving LGs and SGs mimicking IgG4-DS, which suggests that IgG4 testing may be useful in the differentiation of IgG4-DS in the presence of bilateral swelling of LGs or SGs.

元の言語英語
記事番号225
ジャーナルWorld Journal of Surgical Oncology
13
発行部数1
DOI
出版物ステータス出版済み - 7 25 2015

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Mikulicz' Disease
Dacryocystitis
Sialadenitis
Mantle-Cell Lymphoma
Immunoglobulin G
Lacrimal Apparatus
Salivary Glands
Submandibular Gland
Fine Needle Biopsy
Lip
Plasma Cells
Serum
Non-Hodgkin's Lymphoma
Lymphoma
Stomach
Spleen

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. / Hayashi, Yoshikazu; Moriyama, Masafumi; maehara, takashi; Goto, Yuichi; Kawano, Shintarou; Ohta, Miho; Tanaka, Akihiko; Furukawa, Sachiko; Jun-Nosuke, Hayashida; Kiyoshima, Tamotsu; Shimizu, Mayumi; Chikui, Toru; Nakamura, Seiji.

:: World Journal of Surgical Oncology, 巻 13, 番号 1, 225, 25.07.2015.

研究成果: ジャーナルへの寄稿記事

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abstract = "Background: Mantle cell lymphoma (MCL) is a relatively uncommon type of non-Hodgkin lymphoma. It develops in the outer edge of a lymph node called the mantle zone. In contrast, IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by elevated serum IgG4 and persistent bilateral enlargement of lacrimal glands (LGs) and salivary glands (SGs), with infiltration of IgG4-positive plasma cells. Recent studies indicated the importance of differentiation between IgG4-DS and malignant lymphoma. Case presentation: An 82-year-old man was suspected of IgG4-DS because of a high serum IgG level (2174 mg/dL) and bilateral swelling of LGs and SGs. Lip biopsy and fine needle biopsy of submandibular gland were performed, and subsequently, MCL was diagnosed through the histopathological findings. Conclusions: MCL most commonly occurs in the Waldeyer ring, but rarely in the stomach, spleen, skin, LG, and SG. We report an unusual case of MCL involving LGs and SGs mimicking IgG4-DS, which suggests that IgG4 testing may be useful in the differentiation of IgG4-DS in the presence of bilateral swelling of LGs or SGs.",
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AU - Hayashi, Yoshikazu

AU - Moriyama, Masafumi

AU - maehara, takashi

AU - Goto, Yuichi

AU - Kawano, Shintarou

AU - Ohta, Miho

AU - Tanaka, Akihiko

AU - Furukawa, Sachiko

AU - Jun-Nosuke, Hayashida

AU - Kiyoshima, Tamotsu

AU - Shimizu, Mayumi

AU - Chikui, Toru

AU - Nakamura, Seiji

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N2 - Background: Mantle cell lymphoma (MCL) is a relatively uncommon type of non-Hodgkin lymphoma. It develops in the outer edge of a lymph node called the mantle zone. In contrast, IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by elevated serum IgG4 and persistent bilateral enlargement of lacrimal glands (LGs) and salivary glands (SGs), with infiltration of IgG4-positive plasma cells. Recent studies indicated the importance of differentiation between IgG4-DS and malignant lymphoma. Case presentation: An 82-year-old man was suspected of IgG4-DS because of a high serum IgG level (2174 mg/dL) and bilateral swelling of LGs and SGs. Lip biopsy and fine needle biopsy of submandibular gland were performed, and subsequently, MCL was diagnosed through the histopathological findings. Conclusions: MCL most commonly occurs in the Waldeyer ring, but rarely in the stomach, spleen, skin, LG, and SG. We report an unusual case of MCL involving LGs and SGs mimicking IgG4-DS, which suggests that IgG4 testing may be useful in the differentiation of IgG4-DS in the presence of bilateral swelling of LGs or SGs.

AB - Background: Mantle cell lymphoma (MCL) is a relatively uncommon type of non-Hodgkin lymphoma. It develops in the outer edge of a lymph node called the mantle zone. In contrast, IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by elevated serum IgG4 and persistent bilateral enlargement of lacrimal glands (LGs) and salivary glands (SGs), with infiltration of IgG4-positive plasma cells. Recent studies indicated the importance of differentiation between IgG4-DS and malignant lymphoma. Case presentation: An 82-year-old man was suspected of IgG4-DS because of a high serum IgG level (2174 mg/dL) and bilateral swelling of LGs and SGs. Lip biopsy and fine needle biopsy of submandibular gland were performed, and subsequently, MCL was diagnosed through the histopathological findings. Conclusions: MCL most commonly occurs in the Waldeyer ring, but rarely in the stomach, spleen, skin, LG, and SG. We report an unusual case of MCL involving LGs and SGs mimicking IgG4-DS, which suggests that IgG4 testing may be useful in the differentiation of IgG4-DS in the presence of bilateral swelling of LGs or SGs.

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