TY - JOUR
T1 - A case of PBC-AIH overlap syndrome with systemic sclerosis and liver scar
AU - Yamashita, Nobuyuki
AU - Miyagi, Yugo
AU - Simoda, Shinji
AU - Hori, Fumiko
AU - Tanimoto, Hironori
AU - Ichiki, Yasunori
AU - Yamamoto, Hidetaka
AU - Nomura, Hideyuki
PY - 2016
Y1 - 2016
N2 - A sixties year-old man with a history of systemic sclerosis was referred to our hospital because of elevated liver enzymes. Abdominal finding of images showed massive hepatic necrosis near the diaphragm. Elevated ALP, AMA positive, and histological findings as PBC and elevated ALT and histological interface hepatitis findings as AIH indicated the diagnosis as overlap syndrome. Even though this case had good response with corticosteroid and UDCA therapy, hepatic scar and deformation remained after 6 months later. Liver biopsy must be considered aggressively in case of patients with collagen diseases who had elevated liver enzymes.
AB - A sixties year-old man with a history of systemic sclerosis was referred to our hospital because of elevated liver enzymes. Abdominal finding of images showed massive hepatic necrosis near the diaphragm. Elevated ALP, AMA positive, and histological findings as PBC and elevated ALT and histological interface hepatitis findings as AIH indicated the diagnosis as overlap syndrome. Even though this case had good response with corticosteroid and UDCA therapy, hepatic scar and deformation remained after 6 months later. Liver biopsy must be considered aggressively in case of patients with collagen diseases who had elevated liver enzymes.
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U2 - 10.2957/kanzo.57.487
DO - 10.2957/kanzo.57.487
M3 - Article
AN - SCOPUS:84989172869
VL - 57
SP - 487
EP - 495
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
SN - 0451-4203
IS - 9
ER -