A case of recovery from a fulminant type 1 diabetes mellitus-like episode during pregnancy

Saori Shibata, Masanori Iwase, Hiroki Fujii, Udai Nakamura, Nobuhiro Sasaki, Hirofumi Imoto, Naoyuki Nakanami, Mitsuo Iida

研究成果: ジャーナルへの寄稿記事

抄録

A 26-year-old primipara with a positive family history of type 2 diabetes mellitus presented with abrupt onset of thirst, generalized malaise and slight disturbance of consciousness at 11 weeks of gestation. Her BMI was 15.7 kg/m2. Blood chemistry tests revealed a plasma glucose level 1,049 mg/dl, HbA1C of 5.5%, serum total ketone body level of 13,260 μmol/l; arterial blood gas analysis revealed a pH of 7.282 and BE of -17.9 mmol/l. The patient was diagnosed as having diabetic ketoacidosis and started on an intravenous infusion of insulin and saline. The patient tested negative for both anti-GAD antibody and the HLA haplotype associated with type 1 diabetes mellitus. However, the serum levels of exocrine pancreatic enzymes were elevated despite the absense of clinical findings of pancreatitis. After insulin therapy for 3 weeks, the blood glucose levels decreased, and the insulin therapy was discontinued. A 75-g OGTT revealed normal glucose tolerance. Glycemic control was well maintained by diet therapy alone until 39 weeks of gestation, when she delivered a healthy girl vaginally. While the clinical features in our patient resembled those of fulminant type 1 diabetes mellitus at the onset. Endogenous insulin secretion was preserved, and the glucose tolerance became entirely normal following short-term insulin therapy. Recovery from diabetic ketoacidosis during pregnancy is extremely rare.

元の言語英語
ページ(範囲)31-36
ページ数6
ジャーナルJournal of the Japan Diabetes Society
50
発行部数1
出版物ステータス出版済み - 3 14 2007

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Type 1 Diabetes Mellitus
Insulin
Pregnancy
Diabetic Ketoacidosis
Glucose
Diet Therapy
Thirst
Ketone Bodies
Blood Gas Analysis
Hematologic Tests
Glucose Tolerance Test
Serum
Consciousness
Intravenous Infusions
Pancreatitis
Type 2 Diabetes Mellitus
Haplotypes
Blood Glucose
Anti-Idiotypic Antibodies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Shibata, S., Iwase, M., Fujii, H., Nakamura, U., Sasaki, N., Imoto, H., ... Iida, M. (2007). A case of recovery from a fulminant type 1 diabetes mellitus-like episode during pregnancy. Journal of the Japan Diabetes Society, 50(1), 31-36.

A case of recovery from a fulminant type 1 diabetes mellitus-like episode during pregnancy. / Shibata, Saori; Iwase, Masanori; Fujii, Hiroki; Nakamura, Udai; Sasaki, Nobuhiro; Imoto, Hirofumi; Nakanami, Naoyuki; Iida, Mitsuo.

:: Journal of the Japan Diabetes Society, 巻 50, 番号 1, 14.03.2007, p. 31-36.

研究成果: ジャーナルへの寄稿記事

Shibata, S, Iwase, M, Fujii, H, Nakamura, U, Sasaki, N, Imoto, H, Nakanami, N & Iida, M 2007, 'A case of recovery from a fulminant type 1 diabetes mellitus-like episode during pregnancy', Journal of the Japan Diabetes Society, 巻. 50, 番号 1, pp. 31-36.
Shibata, Saori ; Iwase, Masanori ; Fujii, Hiroki ; Nakamura, Udai ; Sasaki, Nobuhiro ; Imoto, Hirofumi ; Nakanami, Naoyuki ; Iida, Mitsuo. / A case of recovery from a fulminant type 1 diabetes mellitus-like episode during pregnancy. :: Journal of the Japan Diabetes Society. 2007 ; 巻 50, 番号 1. pp. 31-36.
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