A case of small cell carcinoma of the stomach with a tubular adenocarcinoma

This paper describes a case of small cell carcinoma of the stomach with a review of 95 cases including the case seen in the Japanese literature. A 67-year-old man was admitted to our hospital complaining of epigastric pain. Barium meal roentgenogram and endoscopic study revealed the Borrmann type 3 lesion at the anterior wall of the upper body of the stomach and the O-IIc + IIa lesion at the posterior wall of the antrum. A total gastrectomy and lymph nodes dissection were performed. There were no liver metastasis, distant metastasis and peritoneal dissemination, but the metastases of #3 and #5 lymph nodes were found. Histopathologically, diffuse proliferation of short spindle-shaped small cells with a high N/C ratio invading to the submucosal layer was noted at the O-IIc + IIa lesion. On immunohistochemical stains, the lesion was positive for chromogranin, NSE and CEA. Based on these findings, a diagnosis of small cell carcinoma of the stomach was made. The Borrmann type 3 lesion showed well to Moderately differentiated tubular adenocarcinoma. Small cell carcinoma of the stomach associated with tubular adenocarcinoma is rare, and only seven cases have been reported in the Japanese literatures.