A Case of Surgical Resection for Gallbladder Cancer with Para-Aortic Lymph Node Metastasis Following Neoadjuvant Chemotherapy with Gemcitabine, Cisplatin, and TS-1

Satoshi Nagaoka, Daisaku Yamada, Hidetoshi Eguchi, Takehiro Noda, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Koji Umeshita, Yuichiro Doki, Masaki Mori

研究成果: ジャーナルへの寄稿記事

抄録

A 60-year-old woman who visited a doctor during postoperative follow-up for breast cancer was found to have elevated CEA levels. Investigation with FDG-PET CT following enhanced CT suggested gallbladder cancer(GBC)accompanied with para-aortic lymph node(PAL)metastasis. Although we could not obtain any histological evidence, we recommended she be treated as a patient with advanced GBC, and she received 8 courses of chemotherapy consisting of gemcitabine, cisplatin, and TS-1, following the protocol of a clinical trial. After the chemotherapy, imaging exhibited down-staging of the GBC, indicating tumor shrinkage and disappearance of the accumulation of FDG at the tumor sites. We first performed cholecystectomy to obtain histological evidence, and subsequently performed pancreaticoduodenectomy and partial hepatectomy at the gallbladder bed. The pathological diagnosis was pT2N1M0, Stage III B, Evans Grade II b; curative grade A surgery was recommended because the PAL did not contain a tumor any more. The prognosis of advanced GBC with PAL metastasis is extremely poor, but conversion therapy with combined modality therapy including neoadjuvant chemotherapy is a useful strategy to achieve a curative resection.

元の言語英語
ページ(範囲)1600-1602
ページ数3
ジャーナルGan to kagaku ryoho. Cancer & chemotherapy
43
発行部数12
出版物ステータス出版済み - 11 1 2016

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gemcitabine
Gallbladder Neoplasms
Cisplatin
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
Combined Modality Therapy
Neoplasms
Pancreaticoduodenectomy
Hepatectomy
Cholecystectomy
Gallbladder
Clinical Trials
Breast Neoplasms
titanium silicide

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

A Case of Surgical Resection for Gallbladder Cancer with Para-Aortic Lymph Node Metastasis Following Neoadjuvant Chemotherapy with Gemcitabine, Cisplatin, and TS-1. / Nagaoka, Satoshi; Yamada, Daisaku; Eguchi, Hidetoshi; Noda, Takehiro; Asaoka, Tadafumi; Wada, Hiroshi; Kawamoto, Koichi; Gotoh, Kunihito; Umeshita, Koji; Doki, Yuichiro; Mori, Masaki.

:: Gan to kagaku ryoho. Cancer & chemotherapy, 巻 43, 番号 12, 01.11.2016, p. 1600-1602.

研究成果: ジャーナルへの寄稿記事

Nagaoka, S, Yamada, D, Eguchi, H, Noda, T, Asaoka, T, Wada, H, Kawamoto, K, Gotoh, K, Umeshita, K, Doki, Y & Mori, M 2016, 'A Case of Surgical Resection for Gallbladder Cancer with Para-Aortic Lymph Node Metastasis Following Neoadjuvant Chemotherapy with Gemcitabine, Cisplatin, and TS-1', Gan to kagaku ryoho. Cancer & chemotherapy, 巻. 43, 番号 12, pp. 1600-1602.
Nagaoka, Satoshi ; Yamada, Daisaku ; Eguchi, Hidetoshi ; Noda, Takehiro ; Asaoka, Tadafumi ; Wada, Hiroshi ; Kawamoto, Koichi ; Gotoh, Kunihito ; Umeshita, Koji ; Doki, Yuichiro ; Mori, Masaki. / A Case of Surgical Resection for Gallbladder Cancer with Para-Aortic Lymph Node Metastasis Following Neoadjuvant Chemotherapy with Gemcitabine, Cisplatin, and TS-1. :: Gan to kagaku ryoho. Cancer & chemotherapy. 2016 ; 巻 43, 番号 12. pp. 1600-1602.
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abstract = "A 60-year-old woman who visited a doctor during postoperative follow-up for breast cancer was found to have elevated CEA levels. Investigation with FDG-PET CT following enhanced CT suggested gallbladder cancer(GBC)accompanied with para-aortic lymph node(PAL)metastasis. Although we could not obtain any histological evidence, we recommended she be treated as a patient with advanced GBC, and she received 8 courses of chemotherapy consisting of gemcitabine, cisplatin, and TS-1, following the protocol of a clinical trial. After the chemotherapy, imaging exhibited down-staging of the GBC, indicating tumor shrinkage and disappearance of the accumulation of FDG at the tumor sites. We first performed cholecystectomy to obtain histological evidence, and subsequently performed pancreaticoduodenectomy and partial hepatectomy at the gallbladder bed. The pathological diagnosis was pT2N1M0, Stage III B, Evans Grade II b; curative grade A surgery was recommended because the PAL did not contain a tumor any more. The prognosis of advanced GBC with PAL metastasis is extremely poor, but conversion therapy with combined modality therapy including neoadjuvant chemotherapy is a useful strategy to achieve a curative resection.",
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AU - Eguchi, Hidetoshi

AU - Noda, Takehiro

AU - Asaoka, Tadafumi

AU - Wada, Hiroshi

AU - Kawamoto, Koichi

AU - Gotoh, Kunihito

AU - Umeshita, Koji

AU - Doki, Yuichiro

AU - Mori, Masaki

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