A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with hypertrophic pachymeningitis

Wataru Shiraishi, Shintaro Hayashi, Yasutaka Iwanaga, Hiroyuki Murai, Akifumi Yamamoto, Jun Ichi Kira

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

A 43-year-old woman with a 3-year history of headache, fever, and swelling of the forehead, presented to our hospital. A general examination revealed palmar and plantar pustules. Blood analyses showed an elevated white blood cell count, C-reactive protein level, and erythrocyte sedimentation rate. Brain MRI revealed a partially thickened cranial bone with gadolinium enhancement, and also abnormally enhanced dura mater. Bone scintigraphy showed involvement of the cranial bone and bilateral sternoclavicular joints. Palmar skin biopsy indicated palmoplantar pustulosis. From these results, SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome with associated hypertrophic pachymeningitis was diagnosed. After corticosteroid therapy and tonsillectomy, the clinical symptoms and radiological abnormalities were improved. Clinicians should be aware of SAPHO as a potential unusual cause of hypertrophic pachymeningitis.

本文言語英語
ページ(範囲)229-231
ページ数3
ジャーナルJournal of the Neurological Sciences
349
1-2
DOI
出版ステータス出版済み - 2 15 2015

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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