A case of type 2 diabetes mellitus with psoriasis vulgaris effectively treated with liraglutide

Ayaka Oshiro, Sakae Nohara, Toshihiko Nagao, Udai Nakamura, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

抄録

We herein report a 72-year-old woman who had type 2 diabetes mellitus for 23 years. She received treatment with 1-mg glimepiride and 50-mg vildagliptin, and her glycated hemoglobin level was 11.9 %. She also had a 10-year history of psoriasis vulgaris, which was being treated with phototherapy and external medicine but was poorly controlled. She was admitted to the hospital for glycemic control, so we discontinued all her medicine and started her on 0.3 mg/day of liraglutide, which we later reduced to 0.3 mg/week. On day 9, her subjective symptoms ameliorated, and her Psoriasis Area and Severity Index score improved from 11.3 to 4.2. Psoriasis vulgaris is a chronic inflammatory disease, and recent reports have found that biological products that target cytokines such as TNF-α are effective as its therapy. GLP-1 inhibitors reportedly affect immune cells and participate in cytokine regulation. The ameliorating effect on psoriatic skin lesions in this case might be related to the GLP-1 inhibitor' s immunological mechanism.

元の言語英語
ページ(範囲)600-605
ページ数6
ジャーナルJournal of the Japan Diabetes Society
61
発行部数9
DOI
出版物ステータス出版済み - 1 1 2018

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Psoriasis
Type 2 Diabetes Mellitus
Glucagon-Like Peptide 1
glimepiride
Medicine
Cytokines
Phototherapy
Glycosylated Hemoglobin A
Biological Products
Chronic Disease
Skin
Therapeutics
Liraglutide

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

A case of type 2 diabetes mellitus with psoriasis vulgaris effectively treated with liraglutide. / Oshiro, Ayaka; Nohara, Sakae; Nagao, Toshihiko; Nakamura, Udai; Kitazono, Takanari.

:: Journal of the Japan Diabetes Society, 巻 61, 番号 9, 01.01.2018, p. 600-605.

研究成果: ジャーナルへの寄稿記事

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