A chromosomal locus encoding a phosphoserine phosphatase- and a truncated MinD-like protein affects differentiation in Streptomyces azureus ATCC14921

Takashi Nishiyama, Hirohito Sakemi, Harukata Sumi, Satoko Tokunaga, Katsumi Doi, Seiya Ogata

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

We isolated BalA1, a representative transformant of thiostrepton- producing strain Streptomyces azureus ATCC14921, which carries an approximately 2.5-kb chromosomal DNA fragment on a high-copy-number plasmid. While strain BalA1 formed little aerial hyphae, its morphological defect was restored by cultivation with S. azureus, S. laurentii, etc. Strain BalA1 strongly inhibited the growth of Bacillus subtilis more than its parent strain, and also inhibited the development of its parent and some Streptomyces strains with thiostrepton resistance. Furthermore, it induced Streptomyces coelicolor A3(2) to produce undecylprodigiosin, at an early stage of growth. The 2.5-kb fragment contained two orfs, orf1 and truncated orf2. The deduced products were somewhat similar to phosphoserine phosphatase-like protein and the N-terminal region of MinD-like protein, respectively. The individual function of orf1 or the function of both orf1 and truncated orf2 seems to induce particular phenotypes or properties in strain BalA1. (C) 2000 Federation of European Microbiological Societies.

本文言語英語
ページ(範囲)133-139
ページ数7
ジャーナルFEMS microbiology letters
190
1
DOI
出版ステータス出版済み - 9 1 2000

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 分子生物学
  • 遺伝学

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