A clinical investigation of oral sarcomas at multi-institutions over the past 30 years

Tomoki Sumida, Naruto Otawa, Yu Kamata, Tomohiro Yamada, Kenichiro Uchida, Hiroyuki Nakano, Hiroyuki Hamakawa, Tetsuya Yamamoto, Yoshiya Ueyama, Yoshihide Mori

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Background/Aim: Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. Patients and Methods: The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of oral and maxillofacial surgery at multi-institutions who had a histopathological diagnosis of malignant oral tumors. Results: Sarcoma accounted for 19 of 1,643 cases (1.16%) in malignant oral tumors. Histologically, osteosarcoma was most common in 6 of the 19 patients, followed by 3 cases each of leiomyo - sarcoma and malignant fibrous histiocytoma, 2 of rhabdomyosarcoma and 1 each of angiosarcoma, Ewing's sarcoma, malignant schwannoma, malignant rhabdoid tumor and undifferentiated sarcoma. Irrespective of the histological type, tumor diameter on initial examination was >50 mm in 8 patients, 7 of whom died. Tumor diameter was <50 mm in 11 patients, 6 of whom survived. Distant metastasis was present in 11 patients, 10 of whom died. The local control rate was 42.1% and 5-year survival rate was 36.8%. Conclusion: Treatment of patients with tumors over 50-mm long in diameter and distant metastasis is extremely difficult. The incidence of oral sarcoma is very low. However, tumor diameter and presence of distant metastasis are important prognostic factors for oral sarcoma according to this multiinstitutional study.

元の言語英語
ページ(範囲)4551-4556
ページ数6
ジャーナルAnticancer Research
35
発行部数8
出版物ステータス出版済み - 8 1 2015

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Sarcoma
Neoplasms
Oral Surgery
Neoplasm Metastasis
Rhabdoid Tumor
Oral Diagnosis
Malignant Fibrous Histiocytoma
Hemangiosarcoma
Ewing's Sarcoma
Neurilemmoma
Osteosarcoma
Mouth
Survival Rate
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

A clinical investigation of oral sarcomas at multi-institutions over the past 30 years. / Sumida, Tomoki; Otawa, Naruto; Kamata, Yu; Yamada, Tomohiro; Uchida, Kenichiro; Nakano, Hiroyuki; Hamakawa, Hiroyuki; Yamamoto, Tetsuya; Ueyama, Yoshiya; Mori, Yoshihide.

:: Anticancer Research, 巻 35, 番号 8, 01.08.2015, p. 4551-4556.

研究成果: ジャーナルへの寄稿記事

Sumida, T, Otawa, N, Kamata, Y, Yamada, T, Uchida, K, Nakano, H, Hamakawa, H, Yamamoto, T, Ueyama, Y & Mori, Y 2015, 'A clinical investigation of oral sarcomas at multi-institutions over the past 30 years', Anticancer Research, 巻. 35, 番号 8, pp. 4551-4556.
Sumida, Tomoki ; Otawa, Naruto ; Kamata, Yu ; Yamada, Tomohiro ; Uchida, Kenichiro ; Nakano, Hiroyuki ; Hamakawa, Hiroyuki ; Yamamoto, Tetsuya ; Ueyama, Yoshiya ; Mori, Yoshihide. / A clinical investigation of oral sarcomas at multi-institutions over the past 30 years. :: Anticancer Research. 2015 ; 巻 35, 番号 8. pp. 4551-4556.
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title = "A clinical investigation of oral sarcomas at multi-institutions over the past 30 years",
abstract = "Background/Aim: Sarcoma of the oral cavity is rare accounting for around 1{\%} of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. Patients and Methods: The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of oral and maxillofacial surgery at multi-institutions who had a histopathological diagnosis of malignant oral tumors. Results: Sarcoma accounted for 19 of 1,643 cases (1.16{\%}) in malignant oral tumors. Histologically, osteosarcoma was most common in 6 of the 19 patients, followed by 3 cases each of leiomyo - sarcoma and malignant fibrous histiocytoma, 2 of rhabdomyosarcoma and 1 each of angiosarcoma, Ewing's sarcoma, malignant schwannoma, malignant rhabdoid tumor and undifferentiated sarcoma. Irrespective of the histological type, tumor diameter on initial examination was >50 mm in 8 patients, 7 of whom died. Tumor diameter was <50 mm in 11 patients, 6 of whom survived. Distant metastasis was present in 11 patients, 10 of whom died. The local control rate was 42.1{\%} and 5-year survival rate was 36.8{\%}. Conclusion: Treatment of patients with tumors over 50-mm long in diameter and distant metastasis is extremely difficult. The incidence of oral sarcoma is very low. However, tumor diameter and presence of distant metastasis are important prognostic factors for oral sarcoma according to this multiinstitutional study.",
author = "Tomoki Sumida and Naruto Otawa and Yu Kamata and Tomohiro Yamada and Kenichiro Uchida and Hiroyuki Nakano and Hiroyuki Hamakawa and Tetsuya Yamamoto and Yoshiya Ueyama and Yoshihide Mori",
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AU - Sumida, Tomoki

AU - Otawa, Naruto

AU - Kamata, Yu

AU - Yamada, Tomohiro

AU - Uchida, Kenichiro

AU - Nakano, Hiroyuki

AU - Hamakawa, Hiroyuki

AU - Yamamoto, Tetsuya

AU - Ueyama, Yoshiya

AU - Mori, Yoshihide

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N2 - Background/Aim: Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. Patients and Methods: The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of oral and maxillofacial surgery at multi-institutions who had a histopathological diagnosis of malignant oral tumors. Results: Sarcoma accounted for 19 of 1,643 cases (1.16%) in malignant oral tumors. Histologically, osteosarcoma was most common in 6 of the 19 patients, followed by 3 cases each of leiomyo - sarcoma and malignant fibrous histiocytoma, 2 of rhabdomyosarcoma and 1 each of angiosarcoma, Ewing's sarcoma, malignant schwannoma, malignant rhabdoid tumor and undifferentiated sarcoma. Irrespective of the histological type, tumor diameter on initial examination was >50 mm in 8 patients, 7 of whom died. Tumor diameter was <50 mm in 11 patients, 6 of whom survived. Distant metastasis was present in 11 patients, 10 of whom died. The local control rate was 42.1% and 5-year survival rate was 36.8%. Conclusion: Treatment of patients with tumors over 50-mm long in diameter and distant metastasis is extremely difficult. The incidence of oral sarcoma is very low. However, tumor diameter and presence of distant metastasis are important prognostic factors for oral sarcoma according to this multiinstitutional study.

AB - Background/Aim: Sarcoma of the oral cavity is rare accounting for around 1% of all malignant oral tumors. The purpose of this study was to find important prognostic factors for patients with oral sarcoma. Patients and Methods: The study included 1,643 patients examined from April 1980 to March 2010 at the Departments of oral and maxillofacial surgery at multi-institutions who had a histopathological diagnosis of malignant oral tumors. Results: Sarcoma accounted for 19 of 1,643 cases (1.16%) in malignant oral tumors. Histologically, osteosarcoma was most common in 6 of the 19 patients, followed by 3 cases each of leiomyo - sarcoma and malignant fibrous histiocytoma, 2 of rhabdomyosarcoma and 1 each of angiosarcoma, Ewing's sarcoma, malignant schwannoma, malignant rhabdoid tumor and undifferentiated sarcoma. Irrespective of the histological type, tumor diameter on initial examination was >50 mm in 8 patients, 7 of whom died. Tumor diameter was <50 mm in 11 patients, 6 of whom survived. Distant metastasis was present in 11 patients, 10 of whom died. The local control rate was 42.1% and 5-year survival rate was 36.8%. Conclusion: Treatment of patients with tumors over 50-mm long in diameter and distant metastasis is extremely difficult. The incidence of oral sarcoma is very low. However, tumor diameter and presence of distant metastasis are important prognostic factors for oral sarcoma according to this multiinstitutional study.

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