A clinical trial of autologous adipose-derived regenerative cell transplantation for a postoperative enterocutaneous fistula

Tsunekazu Mizushima, Hidekazu Takahashi, Hiroshi Takeyama, Atsushi Naito, Naotsugu Haraguchi, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori

研究成果: ジャーナルへの寄稿記事

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Purpose: Adipose-derived stem cell (ADSC) transplantation is expected to be a minimally invasive, but effective, treatment for postoperative enterocutaneous fistulas associated with poor blood flow and chronic inflammation. The aim of this study was to assess the safety and efficacy of a novel ADSC therapy for this condition. Methods: We conducted an open-label, single-arm exploratory phase I study to assess the safety and efficacy of a novel ADSC therapy. Using the Celution system, we isolated adipose-derived regenerative cells (ADRCs) containing abundant ADSCs from liposuction-obtained gluteal adipose tissue. A mixture of ADRCs and fibrin glue was subsequently transplanted into the fistula, and ADRCs were percutaneously and endoscopically injected around the fistula. We evaluated the safety and feasibility of ADRC transplantation and fistula closure in six patients (UMIN000007316). Results: ADRC transplantation was completed in all patients. The fistula closure rates were 83.3 % at 4 and 12 weeks and 100 % at 24 weeks. All patients had grade 1 pain and subcutaneous hemorrhage at the liposuction sites, but no serious adverse events related to this procedure were observed. Conclusions: Transplantation of autologous ADRCs is safe, feasible and advantageous, as it can secure a sufficient cell count without culture or multiple passages, and will likely be effective for a postoperative enterocutaneous fistula.

元の言語英語
ページ(範囲)835-842
ページ数8
ジャーナルSurgery today
46
発行部数7
DOI
出版物ステータス出版済み - 7 1 2016
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Surgery

フィンガープリント A clinical trial of autologous adipose-derived regenerative cell transplantation for a postoperative enterocutaneous fistula' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Mizushima, T., Takahashi, H., Takeyama, H., Naito, A., Haraguchi, N., Uemura, M., Nishimura, J., Hata, T., Takemasa, I., Yamamoto, H., Doki, Y., & Mori, M. (2016). A clinical trial of autologous adipose-derived regenerative cell transplantation for a postoperative enterocutaneous fistula. Surgery today, 46(7), 835-842. https://doi.org/10.1007/s00595-015-1246-8