@article{a6ea8057d7d34c46a745837f5f723346,
title = "A combination of a DNA-chimera siRNA against PLK-1 and zoledronic acid suppresses the growth of malignant mesothelioma cells in vitro",
abstract = "Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell proliferation through the induction of apoptosis. Next, we investigated the effects of zoledronic acid (ZOL) on MM cells, and found that ZOL also induced apoptosis in MM cells. Furthermore, ZOL augmented the inhibitory effects of the PLK-1 siRNA. In conclusion, combining a PLK-1 siRNA with ZOL treatment is an attractive strategy against MM.",
author = "Eri Kawata and Eishi Ashihara and Yoko Nakagawa and Takahiro Kiuchi and Mai Ogura and Hisayuku Yao and Kazuki Sakai and Ruriko Tanaka and Rina Nagao and Asumi Yokota and Miki Takeuchi and Shinya Kimura and Hideyo Hirai and Taira Maekawa",
note = "Funding Information: The authors thank Naoko Hashimoto for her excellent technical assistance. The authors also thank alphaGEN Co, Ltd (Tokyo, Japan) for designing DNA-chimeric siRNAs. The authors declare that they have no commercial affiliations. This work was partly supported by Research for Promoting Technological Seeds, Japan Science and Technology Agency, by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by the Kobayashi Institute for Innovative Cancer Chemotherapy. ",
year = "2010",
month = aug,
doi = "10.1016/j.canlet.2010.02.008",
language = "English",
volume = "294",
pages = "245--253",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
