A comparison of central nervous lesions directly induced by Escherichia coli lipopolysaccharide in piglets, calves, rabbits and mice

Y. Nakajima, Y. Ishikawa, E. Momotani, K. Takahashi, H. Madarame, A. Ito, H. Ueda, M. Wada, Hideyuki Takahashi

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

To evaluate the role of endotoxin during Gram-negative bacterial meningitis, the nervous lesions of piglets, calves, rabbits and mice were compared by direct inoculation of Escherichia coli lipopolysaccharide into the central nervous system. Suppurative leptomeningitis was induced in piglets by small doses of lipopolysaccharide. Mice also had a mild suppurative inflammation in the leptomeninges. In contrast, calves showed suppurative pachymeningitis, but no lesions in the leptomeninges. Leptomeningeal inflammation was not induced in rabbits. Induction of the leptomeningitis by endotoxin was compared with sensitivity to intravenous or intraperitoneal endotoxin in these species.

本文言語英語
ページ(範囲)57-64
ページ数8
ジャーナルJournal of Comparative Pathology
104
1
DOI
出版ステータス出版済み - 1 1 1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • veterinary(all)

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