A comparison of iterative minimum norm estimation and current dipole estimation for magnetic field measurements from small animals

S. Uchida, K. Iramina, K. Goto, S. Ueno

研究成果: Contribution to journalConference article査読

3 被引用数 (Scopus)

抄録

We developed a multi-channel high-resolution SQUID magnetometer for measuring biomagnetic fields produced by small animals. The diameter of the pickup coils in our system is 5 mm, i.e., smaller than typical systems. 12 magnetic fields on a 7.5 mm grid were measured with better spatial resolution than typical systems. We measured the magnetic field response to auditory stimuli in rat brains in a magnetically shielded room. Eight male rats were anesthetized intraperitoneally with Urethane (1 g/1 kg) and stimuli consisting of 3 Hz tone burst sounds were introduced to the left ears. Averaging of the magnetic fields was performed for over 3000 auditory stimuli. The localization of current sources was calculated by two methods, the iterative minimum norm estimation (MNE) and the current dipole model (CDM). Current sources were localized in the auditory area of the right hemisphere in the rat's cortex by iterative MNE. Estimated sources by CDM were localized more deeply than estimated current sources by iterative MNE. The correlation coefficient between the measured magnetic fields and the reconstructed magnetic fields in current sources was higher for iterative MNE than CDM. Iterative MNE is useful for source localization of auditory cortical activities in rats. Our system is a useful and noninvasive tool for brain research in small animals.

本文言語英語
ページ(範囲)3724-3726
ページ数3
ジャーナルIEEE Transactions on Magnetics
36
5 I
DOI
出版ステータス出版済み - 9 2000
外部発表はい
イベント2000 International Magnetics Conference (INTERMAG 2000) - Toronto, Ont, カナダ
継続期間: 4 9 20004 12 2000

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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