A comparison of the cerebrovascular responses to CO2 and diamox in patients with unilateral occlusive cerebral arteries: A H215O PET study

Y. Kuwabara, Y. Ichiya, M. Sasaki, Y. Akashi, T. Yoshida, T. Fukumura, K. Masuda

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

We studied the relationship between the cerebrovascular responses to CO2 and Diamox in patients with chronic cerebrovascular diseases. The subjects consisted of 11 patients with unilateral occlusive or highly stenotic carotid artery. The cerebral blood flow was measured at the resting state, during the inhalation of 5% CO2, at both 5 and 20 min after Diamox i.v. (1 g). The rCBF ratios (occlusive/non-occlusive side) during the inhalation of CO2 and 20 min after Diamox i.v. closely correlated with each other. However, the ratio at 5 min after Diamox i.v. was slightly lower than that during the inhalation of CO2. The percent increases of rCBF also showed a significant correlation between 5% CO2 inhalation and 20 min after Diamox i.v. However, the rCBF decreased inversely at 5 min after Diamox i.v. in some regions on the occlusive side, which indicates the presence of a so-called 'steal phenomenon'. The percent increases in the rCBF after 1 g Diamox i.v. were more or equal to those during the inhalation of 5% CO2. The CO2 and Diamox were thus considered to be equally useful in the evaluation of the perfusion reserve capacity. However, these various characteristics as described above should be considered in the clinical practice.

本文言語英語
ページ(範囲)569-574
ページ数6
ジャーナルKakuigaku
32
6
出版ステータス出版済み - 1 1 1995

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

フィンガープリント 「A comparison of the cerebrovascular responses to CO<sub>2</sub> and diamox in patients with unilateral occlusive cerebral arteries: A H<sub>2</sub><sup>15</sup>O PET study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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