A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: Comparison with chromosome 21q

Yoichi Yamada, Tomoyo Shirakawa, Todd D. Taylor, Kohji Okamura, Hidenobu Soejima, Michiko Uchiyama, Tsuyoshi Iwasaka, Tsunehiro Mukai, Ken Ichiro Muramoto, Yoshiyuki Sakaki, Takashi Ito

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.

本文言語英語
ページ(範囲)300-306
ページ数7
ジャーナルDNA Sequence - Journal of DNA Sequencing and Mapping
17
4
DOI
出版ステータス出版済み - 8 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

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