A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: Comparison with chromosome 21q

Yoichi Yamada, Tomoyo Shirakawa, Todd D. Taylor, Kohji Okamura, Hidenobu Soejima, Michiko Uchiyama, Tsuyoshi Iwasaka, Tsunehiro Mukai, Ken Ichiro Muramoto, Yoshiyuki Sakaki, Takashi Ito

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.

元の言語英語
ページ(範囲)300-306
ページ数7
ジャーナルDNA Sequence - Journal of DNA Sequencing and Mapping
17
発行部数4
DOI
出版物ステータス出版済み - 8 1 2006
外部発表Yes

Fingerprint

CpG Islands
Methylation
Human Chromosomes
Chromosomes
Tandem Repeat Sequences
3' Untranslated Regions
Blood Cells
Blood
Genes
Alleles
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

これを引用

A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q : Comparison with chromosome 21q. / Yamada, Yoichi; Shirakawa, Tomoyo; Taylor, Todd D.; Okamura, Kohji; Soejima, Hidenobu; Uchiyama, Michiko; Iwasaka, Tsuyoshi; Mukai, Tsunehiro; Muramoto, Ken Ichiro; Sakaki, Yoshiyuki; Ito, Takashi.

:: DNA Sequence - Journal of DNA Sequencing and Mapping, 巻 17, 番号 4, 01.08.2006, p. 300-306.

研究成果: ジャーナルへの寄稿記事

Yamada, Y, Shirakawa, T, Taylor, TD, Okamura, K, Soejima, H, Uchiyama, M, Iwasaka, T, Mukai, T, Muramoto, KI, Sakaki, Y & Ito, T 2006, 'A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: Comparison with chromosome 21q', DNA Sequence - Journal of DNA Sequencing and Mapping, 巻. 17, 番号 4, pp. 300-306. https://doi.org/10.1080/10425170600886128
Yamada, Yoichi ; Shirakawa, Tomoyo ; Taylor, Todd D. ; Okamura, Kohji ; Soejima, Hidenobu ; Uchiyama, Michiko ; Iwasaka, Tsuyoshi ; Mukai, Tsunehiro ; Muramoto, Ken Ichiro ; Sakaki, Yoshiyuki ; Ito, Takashi. / A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q : Comparison with chromosome 21q. :: DNA Sequence - Journal of DNA Sequencing and Mapping. 2006 ; 巻 17, 番号 4. pp. 300-306.
@article{aa6fd1e0d8044cfc8b8a9487aaf6be68,
title = "A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: Comparison with chromosome 21q",
abstract = "It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.",
author = "Yoichi Yamada and Tomoyo Shirakawa and Taylor, {Todd D.} and Kohji Okamura and Hidenobu Soejima and Michiko Uchiyama and Tsuyoshi Iwasaka and Tsunehiro Mukai and Muramoto, {Ken Ichiro} and Yoshiyuki Sakaki and Takashi Ito",
year = "2006",
month = "8",
day = "1",
doi = "10.1080/10425170600886128",
language = "English",
volume = "17",
pages = "300--306",
journal = "DNA Sequence - Journal of DNA Sequencing and Mapping",
issn = "1042-5179",
publisher = "Taylor and Francis Ltd.",
number = "4",

}

TY - JOUR

T1 - A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q

T2 - Comparison with chromosome 21q

AU - Yamada, Yoichi

AU - Shirakawa, Tomoyo

AU - Taylor, Todd D.

AU - Okamura, Kohji

AU - Soejima, Hidenobu

AU - Uchiyama, Michiko

AU - Iwasaka, Tsuyoshi

AU - Mukai, Tsunehiro

AU - Muramoto, Ken Ichiro

AU - Sakaki, Yoshiyuki

AU - Ito, Takashi

PY - 2006/8/1

Y1 - 2006/8/1

N2 - It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.

AB - It was generally believed that autosomal CpG islands (CGIs) escape methylation. However, our comprehensive analysis of allelic methylation status of 149 CGIs on human chromosome 21q revealed that a sizable fraction of them are methylated on both alleles even in normal blood cells. Here, we performed a similar analysis of 656 CGIs on chromosome 11q, which is gene-rich in contrast with 21q. The results indicate that 11q contains less methylated CGIs, especially those with tandem repeats and those in the coding or 3′-untranslated regions (UTRs), than 21q. Thus, methylation status of CGIs may substantially differ from one chromosome to another.

UR - http://www.scopus.com/inward/record.url?scp=33847217958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847217958&partnerID=8YFLogxK

U2 - 10.1080/10425170600886128

DO - 10.1080/10425170600886128

M3 - Article

C2 - 17312950

AN - SCOPUS:33847217958

VL - 17

SP - 300

EP - 306

JO - DNA Sequence - Journal of DNA Sequencing and Mapping

JF - DNA Sequence - Journal of DNA Sequencing and Mapping

SN - 1042-5179

IS - 4

ER -