A dual alkylated peptide-ligand enhances affinity to human serum albumin

Elnaz Nakhaei, Ko Takehara, Hikari Sato, Khadijah Zai, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

抄録

Therapeutic peptides and diagnostic agents with their molecular size below the renal clearance threshold suffer from short blood circulation time. Here, we report a novel design of peptide-based ligand with a strong binding affinity to human serum albumin (HSA), which can be used as a tag to extend the blood circulation of small-size molecules. We designed ligands with dual alkyl groups connected with a negatively charged spacer. The ligands showed both higher binding affinity to HSA and a higher retention in mice blood than that of a single alkylated peptide.

元の言語英語
ページ(範囲)501-504
ページ数4
ジャーナルanalytical sciences
34
発行部数4
DOI
出版物ステータス出版済み - 1 1 2018

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Serum Albumin
Hemodynamics
Ligands
Peptides
Blood
Molecules

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

これを引用

A dual alkylated peptide-ligand enhances affinity to human serum albumin. / Nakhaei, Elnaz; Takehara, Ko; Sato, Hikari; Zai, Khadijah; Kishimura, Akihiro; Mori, Takeshi; Katayama, Yoshiki.

:: analytical sciences, 巻 34, 番号 4, 01.01.2018, p. 501-504.

研究成果: ジャーナルへの寄稿記事

Nakhaei, Elnaz ; Takehara, Ko ; Sato, Hikari ; Zai, Khadijah ; Kishimura, Akihiro ; Mori, Takeshi ; Katayama, Yoshiki. / A dual alkylated peptide-ligand enhances affinity to human serum albumin. :: analytical sciences. 2018 ; 巻 34, 番号 4. pp. 501-504.
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