A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors

Kouichi Shiraishi, Reiko Endoh, Hiroshi Furuhata, Masamichi Nishihara, Ryo Suzuki, Kazuo Maruyama, Yusuke Oda, Jun Ichiro Jo, Yasuhiko Tabata, Jun Yamamoto, Masayuki Yokoyama

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

抄録

Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.

元の言語英語
ページ(範囲)379-387
ページ数9
ジャーナルInternational Journal of Pharmaceutics
421
発行部数2
DOI
出版物ステータス出版済み - 12 15 2011

Fingerprint

Emulsions
Neoplasms
Sonication
Phase Transition
Therapeutic Uses
Theranostic Nanomedicine
Baths
Ultrasonics
Temperature

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

これを引用

A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors. / Shiraishi, Kouichi; Endoh, Reiko; Furuhata, Hiroshi; Nishihara, Masamichi; Suzuki, Ryo; Maruyama, Kazuo; Oda, Yusuke; Jo, Jun Ichiro; Tabata, Yasuhiko; Yamamoto, Jun; Yokoyama, Masayuki.

:: International Journal of Pharmaceutics, 巻 421, 番号 2, 15.12.2011, p. 379-387.

研究成果: ジャーナルへの寄稿記事

Shiraishi, K, Endoh, R, Furuhata, H, Nishihara, M, Suzuki, R, Maruyama, K, Oda, Y, Jo, JI, Tabata, Y, Yamamoto, J & Yokoyama, M 2011, 'A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors', International Journal of Pharmaceutics, 巻. 421, 番号 2, pp. 379-387. https://doi.org/10.1016/j.ijpharm.2011.10.006
Shiraishi, Kouichi ; Endoh, Reiko ; Furuhata, Hiroshi ; Nishihara, Masamichi ; Suzuki, Ryo ; Maruyama, Kazuo ; Oda, Yusuke ; Jo, Jun Ichiro ; Tabata, Yasuhiko ; Yamamoto, Jun ; Yokoyama, Masayuki. / A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors. :: International Journal of Pharmaceutics. 2011 ; 巻 421, 番号 2. pp. 379-387.
@article{28f9d7ffdb544c4789730ccf4ca09dfd,
title = "A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors",
abstract = "Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.",
author = "Kouichi Shiraishi and Reiko Endoh and Hiroshi Furuhata and Masamichi Nishihara and Ryo Suzuki and Kazuo Maruyama and Yusuke Oda and Jo, {Jun Ichiro} and Yasuhiko Tabata and Jun Yamamoto and Masayuki Yokoyama",
year = "2011",
month = "12",
day = "15",
doi = "10.1016/j.ijpharm.2011.10.006",
language = "English",
volume = "421",
pages = "379--387",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors

AU - Shiraishi, Kouichi

AU - Endoh, Reiko

AU - Furuhata, Hiroshi

AU - Nishihara, Masamichi

AU - Suzuki, Ryo

AU - Maruyama, Kazuo

AU - Oda, Yusuke

AU - Jo, Jun Ichiro

AU - Tabata, Yasuhiko

AU - Yamamoto, Jun

AU - Yokoyama, Masayuki

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.

AB - Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.

UR - http://www.scopus.com/inward/record.url?scp=81755165811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81755165811&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2011.10.006

DO - 10.1016/j.ijpharm.2011.10.006

M3 - Article

C2 - 22023827

AN - SCOPUS:81755165811

VL - 421

SP - 379

EP - 387

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -