抄録
Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 379-387 |
| ページ数 | 9 |
| ジャーナル | International Journal of Pharmaceutics |
| 巻 | 421 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | 出版済み - 12 15 2011 |
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All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
これを引用
A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors. / Shiraishi, Kouichi; Endoh, Reiko; Furuhata, Hiroshi; Nishihara, Masamichi; Suzuki, Ryo; Maruyama, Kazuo; Oda, Yusuke; Jo, Jun Ichiro; Tabata, Yasuhiko; Yamamoto, Jun; Yokoyama, Masayuki.
：: International Journal of Pharmaceutics, 巻 421, 番号 2, 15.12.2011, p. 379-387.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors
AU - Shiraishi, Kouichi
AU - Endoh, Reiko
AU - Furuhata, Hiroshi
AU - Nishihara, Masamichi
AU - Suzuki, Ryo
AU - Maruyama, Kazuo
AU - Oda, Yusuke
AU - Jo, Jun Ichiro
AU - Tabata, Yasuhiko
AU - Yamamoto, Jun
AU - Yokoyama, Masayuki
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.
AB - Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.
UR - http://www.scopus.com/inward/record.url?scp=81755165811&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81755165811&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2011.10.006
DO - 10.1016/j.ijpharm.2011.10.006
M3 - Article
C2 - 22023827
AN - SCOPUS:81755165811
VL - 421
SP - 379
EP - 387
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 2
ER -