TY - JOUR
T1 - A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors
AU - Shiraishi, Kouichi
AU - Endoh, Reiko
AU - Furuhata, Hiroshi
AU - Nishihara, Masamichi
AU - Suzuki, Ryo
AU - Maruyama, Kazuo
AU - Oda, Yusuke
AU - Jo, Jun Ichiro
AU - Tabata, Yasuhiko
AU - Yamamoto, Jun
AU - Yokoyama, Masayuki
N1 - Funding Information:
This work was supported by the New Energy and Industrial Technology Development Organization, Japan. M. Yokoyama, K. Shiraishi, and M. Nishihara acknowledge support from the JST CREST program, Grant-in-Aid of the Ministry of Education, Culture, Sports, Science and Technology, Japan , and Kanagawa Academy of Science and Technology. The authors acknowledge Dr. Ken-ichi Kawabata and Dr. Rei Asami of Central Research Laboratory, Hitachi, Ltd., for their valuable discussion on PFC-containing nano-emulsions.
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.
AB - Theranostics means a therapy conducted in a diagnosis-guided manner. For theranostics of solid tumors by means of ultrasound, we designed a nano-sized emulsion containing perfluoropentane (PFC5). This emulsion can be delivered into tumor tissues through the tumor vasculatures owing to its nano-size, and the emulsion is transformed into a micron-sized bubble upon sonication through phase transition of PFC5. The micron-sized bubbles can more efficiently absorb ultrasonic energy for better diagnostic images and can exhibit more efficient ultrasound-driven therapeutic effects than nano-sized bubbles. For more efficient tumor delivery, smaller size is preferable, yet the preparation of a smaller emulsion is technically more difficult. In this paper, we used a bath-type sonicator to successfully obtain small PFC5-containing emulsions in a diameter of ca. 200 nm. Additionally, we prepared these small emulsions at 40 °C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method.
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U2 - 10.1016/j.ijpharm.2011.10.006
DO - 10.1016/j.ijpharm.2011.10.006
M3 - Article
C2 - 22023827
AN - SCOPUS:81755165811
VL - 421
SP - 379
EP - 387
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 2
ER -