A flavoenzyme model: Facile oxidation of thiols by a flavin immobilized in cationic polyelectrolytes

Seiji Shinkai, Shinji Yamada, Reiko Ando, Toyoki Kunitake

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

The reactions of a polymer-bound flavin with thiols (2-mercaptoethanol, glutathione, thiophenol, and 1,4-butanedithiol) are remarkably accelerated, when compared with that of a monomeric flavin. The rate enhancements observed were 30- to 6000-fold. In particular, thiophenol which had been believed not to be oxidized by flavin in nonenzymatic systems was oxidized most rapidly among the monothiols examined. The reaction rates were improved by incorporation of a dodecyl group into the flavin-containing polymer. Therefore, the hydrophobic nature of the cationic polymer matrix was concluded to be responsible for the large rate enhancement among other factors.

本文言語英語
ページ(範囲)238-247
ページ数10
ジャーナルBioorganic Chemistry
9
2
DOI
出版ステータス出版済み - 6月 1980

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 創薬
  • 有機化学

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