A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: A case-control study and a meta-analysis

Takahiko Horiuchi, Chikako Kiyohara, Hiroshi Tsukamoto, Takuya Sawabe, Isao Furugo, Seiji Yoshizawa, Akira Ueda, Yoshifumi Tada, Tadashi Nakamura, Yasutaka Kimoto, Hiroki Mitoma, Shinichi Harashima, Shigeru Yoshizawa, Terufumi Shimoda, Seiichi Okamura, Kohei Nagasawa, Mine Harada

研究成果: Contribution to journalArticle査読

41 被引用数 (Scopus)

抄録

Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.

本文言語英語
ページ(範囲)320-324
ページ数5
ジャーナルAnnals of the Rheumatic Diseases
66
3
DOI
出版ステータス出版済み - 3 2007

All Science Journal Classification (ASJC) codes

  • リウマチ学
  • 免疫アレルギー学
  • 免疫学
  • 生化学、遺伝学、分子生物学(全般)

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