A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus

A case-control study and a meta-analysis

Takahiko Horiuchi, Chikako Kiyohara, Hiroshi Tsukamoto, Takuya Sawabe, Isao Furugo, Seiji Yoshizawa, Akira Ueda, Yoshifumi Tada, Tadashi Nakamura, yasutaka kimoto, Hiroki Mitoma, Shinichi Harashima, Shigeru Yoshizawa, Terufumi Shimoda, Seiichi Okamura, Kohei Nagasawa, Mine Harada

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

抄録

Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.

元の言語英語
ページ(範囲)320-324
ページ数5
ジャーナルAnnals of the Rheumatic Diseases
66
発行部数3
DOI
出版物ステータス出版済み - 3 1 2007

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Receptors, Tumor Necrosis Factor, Type II
Polymorphism
Systemic Lupus Erythematosus
Meta-Analysis
Case-Control Studies
Association reactions
Alleles
Odds Ratio
Confidence Intervals
Population
Polymerase chain reaction
Nucleotides
Conformations
Genotype
Screening
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus : A case-control study and a meta-analysis. / Horiuchi, Takahiko; Kiyohara, Chikako; Tsukamoto, Hiroshi; Sawabe, Takuya; Furugo, Isao; Yoshizawa, Seiji; Ueda, Akira; Tada, Yoshifumi; Nakamura, Tadashi; kimoto, yasutaka; Mitoma, Hiroki; Harashima, Shinichi; Yoshizawa, Shigeru; Shimoda, Terufumi; Okamura, Seiichi; Nagasawa, Kohei; Harada, Mine.

:: Annals of the Rheumatic Diseases, 巻 66, 番号 3, 01.03.2007, p. 320-324.

研究成果: ジャーナルへの寄稿記事

Horiuchi, T, Kiyohara, C, Tsukamoto, H, Sawabe, T, Furugo, I, Yoshizawa, S, Ueda, A, Tada, Y, Nakamura, T, kimoto, Y, Mitoma, H, Harashima, S, Yoshizawa, S, Shimoda, T, Okamura, S, Nagasawa, K & Harada, M 2007, 'A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: A case-control study and a meta-analysis', Annals of the Rheumatic Diseases, 巻. 66, 番号 3, pp. 320-324. https://doi.org/10.1136/ard.2006.058917
Horiuchi, Takahiko ; Kiyohara, Chikako ; Tsukamoto, Hiroshi ; Sawabe, Takuya ; Furugo, Isao ; Yoshizawa, Seiji ; Ueda, Akira ; Tada, Yoshifumi ; Nakamura, Tadashi ; kimoto, yasutaka ; Mitoma, Hiroki ; Harashima, Shinichi ; Yoshizawa, Shigeru ; Shimoda, Terufumi ; Okamura, Seiichi ; Nagasawa, Kohei ; Harada, Mine. / A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus : A case-control study and a meta-analysis. :: Annals of the Rheumatic Diseases. 2007 ; 巻 66, 番号 3. pp. 320-324.
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abstract = "Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95{\%} confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95{\%} CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.",
author = "Takahiko Horiuchi and Chikako Kiyohara and Hiroshi Tsukamoto and Takuya Sawabe and Isao Furugo and Seiji Yoshizawa and Akira Ueda and Yoshifumi Tada and Tadashi Nakamura and yasutaka kimoto and Hiroki Mitoma and Shinichi Harashima and Shigeru Yoshizawa and Terufumi Shimoda and Seiichi Okamura and Kohei Nagasawa and Mine Harada",
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T1 - A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus

T2 - A case-control study and a meta-analysis

AU - Horiuchi, Takahiko

AU - Kiyohara, Chikako

AU - Tsukamoto, Hiroshi

AU - Sawabe, Takuya

AU - Furugo, Isao

AU - Yoshizawa, Seiji

AU - Ueda, Akira

AU - Tada, Yoshifumi

AU - Nakamura, Tadashi

AU - kimoto, yasutaka

AU - Mitoma, Hiroki

AU - Harashima, Shinichi

AU - Yoshizawa, Shigeru

AU - Shimoda, Terufumi

AU - Okamura, Seiichi

AU - Nagasawa, Kohei

AU - Harada, Mine

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.

AB - Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.

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