抄録
Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 320-324 |
| ページ数 | 5 |
| ジャーナル | Annals of the Rheumatic Diseases |
| 巻 | 66 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 3 1 2007 |
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All Science Journal Classification (ASJC) codes
- Rheumatology
- Immunology and Allergy
- Immunology
- Biochemistry, Genetics and Molecular Biology(all)
これを引用
A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus : A case-control study and a meta-analysis. / Horiuchi, Takahiko; Kiyohara, Chikako; Tsukamoto, Hiroshi; Sawabe, Takuya; Furugo, Isao; Yoshizawa, Seiji; Ueda, Akira; Tada, Yoshifumi; Nakamura, Tadashi; kimoto, yasutaka; Mitoma, Hiroki; Harashima, Shinichi; Yoshizawa, Shigeru; Shimoda, Terufumi; Okamura, Seiichi; Nagasawa, Kohei; Harada, Mine.
：: Annals of the Rheumatic Diseases, 巻 66, 番号 3, 01.03.2007, p. 320-324.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus
T2 - A case-control study and a meta-analysis
AU - Horiuchi, Takahiko
AU - Kiyohara, Chikako
AU - Tsukamoto, Hiroshi
AU - Sawabe, Takuya
AU - Furugo, Isao
AU - Yoshizawa, Seiji
AU - Ueda, Akira
AU - Tada, Yoshifumi
AU - Nakamura, Tadashi
AU - kimoto, yasutaka
AU - Mitoma, Hiroki
AU - Harashima, Shinichi
AU - Yoshizawa, Shigeru
AU - Shimoda, Terufumi
AU - Okamura, Seiichi
AU - Nagasawa, Kohei
AU - Harada, Mine
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.
AB - Objectives: To perform a case-control study of a functional M196R polymorphism of tumour necrosis factor receptor type 2 (TNF-RII) in a Japanese population and a meta-analysis of all published reports on the polymorphism to investigate the association of the M196R polymorphism of TNF-RII with systemic lupus erythematosus (SLE). Methods: The functional M196R polymorphism of TNF-RII was genotyped by using polymerase chain reaction combined with the subsequent single-strand conformation polymorphism (PCR-SSCP) analysis for screening, followed by nucleotide sequencing for confirmation. A total of 331 patients and 359 controls were subjected to a case-control study. A meta-analysis of the available case-control studies including all published data as well as our own data was performed to investigate the association of the functional M196R polymorphism of TNF-RII with SLE. Results: Our case-control study did not show any significant association of a functional M196R polymorphism of TNF-RII with SLE, although there was a trend towards association. A meta-analysis of seven case-control studies in eight different ethnic populations including our own showed that 196M/R and 196R/R genotypes combined was significantly associated with an increased risk of SLE (odds ratio (OR) 1.29, 95% confidence interval (CI) 1.04 to 1.60; p = 0.02). Stratification by ethnicity showed a more significant association in Asians, including Japanese, Korean and Vietnamese (OR 1.40, 95% CI 1.10 to 1.78; p = 0.006). The effect of the 196R allele on SLE was not clear in Caucasians. Conclusions: The 196R allele of the functional M196R polymorphism of TNF-RII is a risk factor for SLE, especially in the Asian population.
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UR - http://www.scopus.com/inward/citedby.url?scp=34147198192&partnerID=8YFLogxK
U2 - 10.1136/ard.2006.058917
DO - 10.1136/ard.2006.058917
M3 - Article
VL - 66
SP - 320
EP - 324
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 3
ER -