@article{16a4df38fb97414a8bc6689edf246572,
title = "A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities",
abstract = "Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-{\^e}{\^A} and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.",
author = "Yuta Kochi and Ryo Yamada and Akari Suzuki and Harley, {John B.} and Senji Shirasawa and Tetsuji Sawada and Bae, {Sang Cheol} and Shinya Tokuhiro and Xiaotian Chang and Akihiro Sekine and Atsushi Takahashi and Tatsuhiko Tsunoda and Yozo Ohnishi and Kaufman, {Kenneth M.} and Kang, {Changsoo Paul} and Changwon Kang and Shigeru Otsubo and Wako Yumura and Akio Mimori and Takao Koike and Yusuke Nakamura and Takehiko Sasazuki and Kazuhiko Yamamoto",
note = "Funding Information: We thank E. Kanno and other members of the Laboratory for Rheumatic Diseases for technical assistance; H. Kawakami for expertise in computer programming; M. Yukioka, S. Tohma, Y. Nishioka, T. Matsubara, S. Wakitani, R. Teshima, N. Ishikawa, K. Ito, K. Ito, K. Kuma, H. Tamai and T. Akamizu for clinical sample collection; M. Ishikawa and Y. Amasaki for preparation of the second population study; M. Nagashima and S. Yoshino for sampling rheumatoid arthritis synovium; and K. Nagatani and Y. Komagata for advice. This work was supported by grants from the Japanese Millennium Project, the US National Institutes of Health and the Korean Molecular and Cellular BioDiscovery Research Program.",
year = "2005",
month = may,
doi = "10.1038/ng1540",
language = "English",
volume = "37",
pages = "478--485",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "5",
}