TY - JOUR
T1 - A genome-wide association study identifies 2 susceptibility loci for crohn's disease in a Japanese population
AU - Yamazaki, Keiko
AU - Umeno, Junji
AU - Takahashi, Atsushi
AU - Hirano, Atsushi
AU - Johnson, Todd Andrew
AU - Kumasaka, Natsuhiko
AU - Morizono, Takashi
AU - Hosono, Naoya
AU - Kawaguchi, Takaaki
AU - Takazoe, Masakazu
AU - Yamada, Tetsuhiro
AU - Suzuki, Yasuo
AU - Tanaka, Hiroki
AU - Motoya, Satoshi
AU - Hosokawa, Masayo
AU - Arimura, Yoshiaki
AU - Shinomura, Yasuhisa
AU - Matsui, Toshiyuki
AU - Matsumoto, Takayuki
AU - Iida, Mitsuo
AU - Tsunoda, Tatsuhiko
AU - Nakamura, Yusuke
AU - Kamatani, Naoyuki
AU - Kubo, Michiaki
N1 - Funding Information:
Y. Hou is thankful for the support from the National Natural Science Foundation of China (51702284, 21878270, and 21922811), the Zhejiang Provincial Natural Science Foundation of China (LR19B060002), and the Startup Foundation for Hundred-Talent Program of Zhejiang University.
PY - 2013/4
Y1 - 2013/4
N2 - Background & Aims: Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population. Methods: We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort. Results: We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10 -59), TNFSF15 (rs6478106, P = 3.87 × 10-45), and STAT3 (rs9891119, P = 2.24 × 10-14). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10 -11; odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10-9; odds ratio, 1.27). Conclusions: In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.
AB - Background & Aims: Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified genetic factors that affect the risk for Crohn's disease in European populations, but information from other ethnic groups is scarce. We therefore investigated genetic factors associated with Crohn's disease in the Japanese population. Methods: We performed a genome-wide association study with 372 individuals with Crohn's disease (cases) and 3389 controls, all from the Japanese population. To confirm identified associations, we performed a replication study with an independent panel of 1151 Crohn's disease cases and 15,800 controls. We also performed an association analysis using genome-wide genotype imputation in the discovery cohort. Results: We confirmed associations of Crohn's disease with variants in MHC (rs7765379, P = 2.11 × 10 -59), TNFSF15 (rs6478106, P = 3.87 × 10-45), and STAT3 (rs9891119, P = 2.24 × 10-14). We identified 2 new susceptibility loci: on chromosome 4p14 (rs1487630, P = 2.40 × 10 -11; odds ratio, 1.33), and in the SLC25A15-ELF1-WBP4 region on 13q14 (rs7329174 in ELF1, P = 5.12 × 10-9; odds ratio, 1.27). Conclusions: In a genome-wide association study, we identified 2 new susceptibility loci for Crohn's disease in a Japanese population. These findings could increase our understanding of the pathogenesis of Crohn's disease.
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U2 - 10.1053/j.gastro.2012.12.021
DO - 10.1053/j.gastro.2012.12.021
M3 - Article
C2 - 23266558
AN - SCOPUS:84875234775
VL - 144
SP - 781
EP - 788
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 4
ER -