A heterodimeric DNA polymerase: Evidence that members of Euryarchaeota possess a distinct DNA polymerase

Isaac K.O. Cann, Kayoko Komori, Hiroyuki Toh, Satoru Kanai, Yoshizumi Ishino

研究成果: Contribution to journalArticle査読

116 被引用数 (Scopus)

抄録

We describe here a DNA polymerase family highly conserved in Euryarchaeota, a subdomain of Archaea. The DNA polymerase is composed of two proteins, DP1 and DP2. Sequence analysis showed that considerable similarity exists between DP1 and the second subunit of eukaryotic DNA polymerase δ, a protein essential for the propagation of Eukarya, and that DP2 has conserved motifs found in proteins with nucleotide-polymerizing activity. These results, together with our previous biochemical analyses of one of the members, DNA polymerase II (DP1 + DP2) from Pyrococcus furiosus, implicate the DNA polymerases of this family in the DNA replication process of Euryarchaeota. The discovery of this DNA-polymerase family, aside from providing an opportunity to enhance our knowledge of the evolution of DNA polymerases, is a significant step toward the complete understanding of DNA replication across the three domains of life.

本文言語英語
ページ(範囲)14250-14255
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
95
24
DOI
出版ステータス出版済み - 11 24 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • General

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