A Highly Practical Synthesis of Sulfated Lewis X: One-Pot, Two-Step Glycosylation Using "Armed/Disarmed" Coupling and Selective Benzoylation and Sulfation

Takahiro Tsukida, Masahiro Yoshida, Kiriko Kurokawa, Yoshiyuki Nakai, Toshio Achiha, Takao Kiyoi, Hirosato Kondo

研究成果: Contribution to journalArticle

48 被引用数 (Scopus)

抄録

In spite of the several attractive biological activities of the Lex, sLex, and sulfated Lex derivatives, there are still limitations in their practical syntheses. One of the most difficult problems is the many steps required for their syntheses. Therefore, we investigated simple constructions of the Lex analogs and succeeded in establishing highly practical syntheses of the Lex and sulfated Lex analogs. Especially, the "armed/disarmed" method allowed the first synthesis of Lex derivatives by a one-pot, two-step glycosylation. This synthetic strategy could be an applicable and useful method for oligosaccharide constructions of Lex, sulfated Lex, and other derivatives.

本文言語英語
ページ(範囲)6876-6881
ページ数6
ジャーナルJournal of Organic Chemistry
62
20
DOI
出版ステータス出版済み - 1 1 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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