A highly stereoselective synthesis of a key intermediate of 1β-methylcarbapenems employing the reformatsky reaction of 3-(2-bromopropionyl)-2-oxazolidone derivatives

Yoshio Ito, Shiro Terashima

研究成果: Contribution to journalArticle査読

43 被引用数 (Scopus)

抄録

Reaction of sterically crowded achiral 3-(2-bromopropionyl)-2-oxazolidone derivatives with (3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone in the presence of zinc dust in refluxing tetrahydrofuran was found to give the 1β-methyl substituted β-lactams as major products (at most, β:α=95:5). The major products were readily converted into the key intermediate of 1β-methylcarbapenems.

本文言語英語
ページ(範囲)6625-6628
ページ数4
ジャーナルTetrahedron Letters
28
52
DOI
出版ステータス出版済み - 1987
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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