抄録
Reaction of sterically crowded achiral 3-(2-bromopropionyl)-2-oxazolidone derivatives with (3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone in the presence of zinc dust in refluxing tetrahydrofuran was found to give the 1β-methyl substituted β-lactams as major products (at most, β:α=95:5). The major products were readily converted into the key intermediate of 1β-methylcarbapenems.
本文言語 | 英語 |
---|---|
ページ(範囲) | 6625-6628 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 28 |
号 | 52 |
DOI | |
出版ステータス | 出版済み - 1987 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 生化学
- 創薬
- 有機化学