A horseshoe crab receptor structurally related to Drosophila Toll

K. I. Inamori, K. Koori, C. Mishima, T. Muta, Shun-Ichiro Kawabata

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

Innate immunity against microbial pathogens relies on the pattern recognition of cell wall components on invading microbes. Recent evidence has shown that a mammalian Toll-like receptor (TLR) is activated by bacterial lipopolysaccharides (LPS). The innate immunity in invertebrates is also triggered by LPS, as seen in the hemolymph coagulation in horseshoe crab. We report the cloning of a TLR from the Japanese horseshoe crab Tachypleus tridentatus. A cDNA coding for Tachypleus Toll was isolated from a hemocyte cDNA library and the open reading frame codes for a proprotein including a signal sequence. Like Drosophila Toll, Tachypleus Toll is a type I transmembrane protein with an extracellular domain consisting of two leucine-rich repeats flanked by two cystein-rich clusters and a cytoplasmic domain exhibiting striking similarity with the cytoplasmic domain of interleukin-1 receptor. Tachypleus Toll is most similar to Drosophila Toll in the domain architecture and the overall length.

元の言語英語
ページ(範囲)397-399
ページ数3
ジャーナルJournal of Endotoxin Research
6
発行部数5
DOI
出版物ステータス出版済み - 12 1 2000

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Horseshoe Crabs
Toll-Like Receptors
Drosophila
Lipopolysaccharides
Interleukin-1 Receptors
Cloning
Pathogens
Protein Sorting Signals
Coagulation
Gene Library
Leucine
Pattern recognition
Complementary DNA
Cells
Innate Immunity
Hemocytes
Proteins
Hemolymph
Cellular Structures
Invertebrates

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases

これを引用

A horseshoe crab receptor structurally related to Drosophila Toll. / Inamori, K. I.; Koori, K.; Mishima, C.; Muta, T.; Kawabata, Shun-Ichiro.

:: Journal of Endotoxin Research, 巻 6, 番号 5, 01.12.2000, p. 397-399.

研究成果: ジャーナルへの寄稿記事

Inamori, K. I. ; Koori, K. ; Mishima, C. ; Muta, T. ; Kawabata, Shun-Ichiro. / A horseshoe crab receptor structurally related to Drosophila Toll. :: Journal of Endotoxin Research. 2000 ; 巻 6, 番号 5. pp. 397-399.
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