A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

Yusuke Yanagi, Yasunobu Yoshikai, Kathleen Leggett, Stephen P. Clark, Ingrid Aleksander, Tak W. Mak

    研究成果: ジャーナルへの寄稿記事

    825 引用 (Scopus)

    抄録

    We have cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells. The message was found to be expressed in human and murine T lymphoblasts, thymocytes and phytohaemagglutinin-stimulated T lymphocytes. The protein deduced from the cDNA sequence has a molecular weight of 34,938 and shows extensive similarity to the entire length of the variable, joining and constant regions of mammalian immunoglobulin light chains. In addition, the relative positions of the cysteine residues are similar to those of the light chains of murine and human immunoglobulin molecules. These properties suggest that the cDNA clone may correspond to a message that specifies part of the human T-cell receptor.

    元の言語英語
    ページ(範囲)145-149
    ページ数5
    ジャーナルNature
    308
    発行部数5955
    DOI
    出版物ステータス出版済み - 12 1 1984

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    Immunoglobulin Subunits
    Complementary DNA
    Clone Cells
    T-Lymphocytes
    Proteins
    Immunoglobulin Light Chains
    Phytohemagglutinins
    Thymocytes
    T-Cell Antigen Receptor
    Cysteine
    Immunoglobulins
    Molecular Weight
    Lymphocytes
    Light
    Messenger RNA

    All Science Journal Classification (ASJC) codes

    • General

    これを引用

    Yanagi, Y., Yoshikai, Y., Leggett, K., Clark, S. P., Aleksander, I., & Mak, T. W. (1984). A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature, 308(5955), 145-149. https://doi.org/10.1038/308145a0

    A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. / Yanagi, Yusuke; Yoshikai, Yasunobu; Leggett, Kathleen; Clark, Stephen P.; Aleksander, Ingrid; Mak, Tak W.

    :: Nature, 巻 308, 番号 5955, 01.12.1984, p. 145-149.

    研究成果: ジャーナルへの寄稿記事

    Yanagi, Y, Yoshikai, Y, Leggett, K, Clark, SP, Aleksander, I & Mak, TW 1984, 'A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains', Nature, 巻. 308, 番号 5955, pp. 145-149. https://doi.org/10.1038/308145a0
    Yanagi, Yusuke ; Yoshikai, Yasunobu ; Leggett, Kathleen ; Clark, Stephen P. ; Aleksander, Ingrid ; Mak, Tak W. / A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. :: Nature. 1984 ; 巻 308, 番号 5955. pp. 145-149.
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    abstract = "We have cloned and sequenced a human mRNA specific for mammalian T-lymphoid cells. The message was found to be expressed in human and murine T lymphoblasts, thymocytes and phytohaemagglutinin-stimulated T lymphocytes. The protein deduced from the cDNA sequence has a molecular weight of 34,938 and shows extensive similarity to the entire length of the variable, joining and constant regions of mammalian immunoglobulin light chains. In addition, the relative positions of the cysteine residues are similar to those of the light chains of murine and human immunoglobulin molecules. These properties suggest that the cDNA clone may correspond to a message that specifies part of the human T-cell receptor.",
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    AU - Mak, Tak W.

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