A human T cell‐specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein‐tyrosine kinases

Yasuhiro Koga, Nicolette Caccia, Barry Toyonaga, Rosanne Spolski, Yusuke Yanagi, Yasunobu Yoshikai, Tak W. Mak

    研究成果: ジャーナルへの寄稿記事

    58 引用 (Scopus)

    抄録

    We report here the isolation of a human T cell‐specific cDNA clone (YT16) that encodes a protein with extensive homology to a family of transformation and proliferation‐related protein‐tyrosine kinases (PTK). The message size of YT16 is 2.2 kb and it encodes a protein of 507 amino acids with a mol. mass of 57136 Daltons. The deduced protein sequence has an overall homology of about 50% to the viral oncogene products of src and yes. Around the PTK catalytic domain, the homologies increase to 70–80% between the deduced protein sequence of YT16 and those of the PTK viral oncogenes. Of special interest is the extensive homology between the deduced protein sequence of YT16 and that of a recently reported murine B and T lymphocyte‐specific PTK, lskT. It is possible that YT16 either encodes the human homologue of this murine gene, or a protein with similar function(s) in T cells.

    元の言語英語
    ページ(範囲)1643-1646
    ページ数4
    ジャーナルEuropean Journal of Immunology
    16
    発行部数12
    DOI
    出版物ステータス出版済み - 1 1 1986

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    Phosphotransferases
    Complementary DNA
    Clone Cells
    Proteins
    Oncogene Proteins
    Oncogenes
    Catalytic Domain
    T-Lymphocytes
    Amino Acids
    Genes

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    これを引用

    A human T cell‐specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein‐tyrosine kinases. / Koga, Yasuhiro; Caccia, Nicolette; Toyonaga, Barry; Spolski, Rosanne; Yanagi, Yusuke; Yoshikai, Yasunobu; Mak, Tak W.

    :: European Journal of Immunology, 巻 16, 番号 12, 01.01.1986, p. 1643-1646.

    研究成果: ジャーナルへの寄稿記事

    Koga, Yasuhiro ; Caccia, Nicolette ; Toyonaga, Barry ; Spolski, Rosanne ; Yanagi, Yusuke ; Yoshikai, Yasunobu ; Mak, Tak W. / A human T cell‐specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein‐tyrosine kinases. :: European Journal of Immunology. 1986 ; 巻 16, 番号 12. pp. 1643-1646.
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    abstract = "We report here the isolation of a human T cell‐specific cDNA clone (YT16) that encodes a protein with extensive homology to a family of transformation and proliferation‐related protein‐tyrosine kinases (PTK). The message size of YT16 is 2.2 kb and it encodes a protein of 507 amino acids with a mol. mass of 57136 Daltons. The deduced protein sequence has an overall homology of about 50{\%} to the viral oncogene products of src and yes. Around the PTK catalytic domain, the homologies increase to 70–80{\%} between the deduced protein sequence of YT16 and those of the PTK viral oncogenes. Of special interest is the extensive homology between the deduced protein sequence of YT16 and that of a recently reported murine B and T lymphocyte‐specific PTK, lskT. It is possible that YT16 either encodes the human homologue of this murine gene, or a protein with similar function(s) in T cells.",
    author = "Yasuhiro Koga and Nicolette Caccia and Barry Toyonaga and Rosanne Spolski and Yusuke Yanagi and Yasunobu Yoshikai and Mak, {Tak W.}",
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    T1 - A human T cell‐specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein‐tyrosine kinases

    AU - Koga, Yasuhiro

    AU - Caccia, Nicolette

    AU - Toyonaga, Barry

    AU - Spolski, Rosanne

    AU - Yanagi, Yusuke

    AU - Yoshikai, Yasunobu

    AU - Mak, Tak W.

    PY - 1986/1/1

    Y1 - 1986/1/1

    N2 - We report here the isolation of a human T cell‐specific cDNA clone (YT16) that encodes a protein with extensive homology to a family of transformation and proliferation‐related protein‐tyrosine kinases (PTK). The message size of YT16 is 2.2 kb and it encodes a protein of 507 amino acids with a mol. mass of 57136 Daltons. The deduced protein sequence has an overall homology of about 50% to the viral oncogene products of src and yes. Around the PTK catalytic domain, the homologies increase to 70–80% between the deduced protein sequence of YT16 and those of the PTK viral oncogenes. Of special interest is the extensive homology between the deduced protein sequence of YT16 and that of a recently reported murine B and T lymphocyte‐specific PTK, lskT. It is possible that YT16 either encodes the human homologue of this murine gene, or a protein with similar function(s) in T cells.

    AB - We report here the isolation of a human T cell‐specific cDNA clone (YT16) that encodes a protein with extensive homology to a family of transformation and proliferation‐related protein‐tyrosine kinases (PTK). The message size of YT16 is 2.2 kb and it encodes a protein of 507 amino acids with a mol. mass of 57136 Daltons. The deduced protein sequence has an overall homology of about 50% to the viral oncogene products of src and yes. Around the PTK catalytic domain, the homologies increase to 70–80% between the deduced protein sequence of YT16 and those of the PTK viral oncogenes. Of special interest is the extensive homology between the deduced protein sequence of YT16 and that of a recently reported murine B and T lymphocyte‐specific PTK, lskT. It is possible that YT16 either encodes the human homologue of this murine gene, or a protein with similar function(s) in T cells.

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