A LINE 1 sequence interrupts the rat α2u globulin gene

Mikio Yamamoto, Feng Gao, Masato Furuichi, Yuji Ichiyoshi, Hideya Endo

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The rat α2u globulin gene family is composed of about 25 members with closely related structure. Several of these genes are transcriptionally active in the liver of adult males. We isolated about 50 independent genomic clones from the library and determined complete nucleotide sequences of two. Although they were alike and revealed structural features prerequisite for active genes, one cloned gene was interrupted in the 6th intron with about 900 bp 5′ truncated and 3′-terminal triplicated form of LINE 1 sequence flanked by 16 bp complete direct repeat originating from the 6th intron. Within the inserted LINE 1 an excellent splicing acceptor homologue with a precedent lariat junction motif and multiple polyadenylation signals was identified. Thus, the possible production of a chimeric RNA, the last exon of which would be replaced by a part of LINE 1, has to be considered.

本文言語英語
ページ(範囲)322-328
ページ数7
ジャーナルBBA - Gene Structure and Expression
1008
3
DOI
出版ステータス出版済み - 8 14 1989

All Science Journal Classification (ASJC) codes

  • 構造生物学
  • 生物理学
  • 生化学
  • 遺伝学

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