A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

Tomohiro Iguchi, Ryutaro Uchi, Sho Nambara, Tomoko Saito, Hisateru Komatsu, Hidenari Hirata, Masami Ueda, Shotaro Sakimura, Yuki Takano, Jyunji Kurashige, Yoshiaki Shinden, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

134 引用 (Scopus)


Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

ジャーナルAnticancer research
出版物ステータス出版済み - 3 1 2015


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research