A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

Tomohiro Iguchi, Ryutaro Uchi, Sho Nambara, Tomoko Saito, Hisateru Komatsu, Hidenari Hirata, Masami Ueda, Shotaro Sakimura, Yuki Takano, Jyunji Kurashige, Yoshiaki Shinden, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

116 引用 (Scopus)

抄録

Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

元の言語英語
ページ(範囲)1385-1388
ページ数4
ジャーナルAnticancer research
35
発行部数3
出版物ステータス出版済み - 3 1 2015

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Long Noncoding RNA
Colorectal Neoplasms
Neoplasm Metastasis
Transforming Growth Factors
Reverse Transcription
Blood Vessels
Hepatocellular Carcinoma
Neoplasms
Lymph Nodes
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Iguchi, T., Uchi, R., Nambara, S., Saito, T., Komatsu, H., Hirata, H., ... Mimori, K. (2015). A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. Anticancer research, 35(3), 1385-1388.

A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. / Iguchi, Tomohiro; Uchi, Ryutaro; Nambara, Sho; Saito, Tomoko; Komatsu, Hisateru; Hirata, Hidenari; Ueda, Masami; Sakimura, Shotaro; Takano, Yuki; Kurashige, Jyunji; Shinden, Yoshiaki; Eguchi, Hidetoshi; Sugimachi, Keishi; Maehara, Yoshihiko; Mimori, Koshi.

:: Anticancer research, 巻 35, 番号 3, 01.03.2015, p. 1385-1388.

研究成果: ジャーナルへの寄稿記事

Iguchi, T, Uchi, R, Nambara, S, Saito, T, Komatsu, H, Hirata, H, Ueda, M, Sakimura, S, Takano, Y, Kurashige, J, Shinden, Y, Eguchi, H, Sugimachi, K, Maehara, Y & Mimori, K 2015, 'A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer', Anticancer research, 巻. 35, 番号 3, pp. 1385-1388.
Iguchi T, Uchi R, Nambara S, Saito T, Komatsu H, Hirata H その他. A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. Anticancer research. 2015 3 1;35(3):1385-1388.
Iguchi, Tomohiro ; Uchi, Ryutaro ; Nambara, Sho ; Saito, Tomoko ; Komatsu, Hisateru ; Hirata, Hidenari ; Ueda, Masami ; Sakimura, Shotaro ; Takano, Yuki ; Kurashige, Jyunji ; Shinden, Yoshiaki ; Eguchi, Hidetoshi ; Sugimachi, Keishi ; Maehara, Yoshihiko ; Mimori, Koshi. / A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. :: Anticancer research. 2015 ; 巻 35, 番号 3. pp. 1385-1388.
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abstract = "Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.",
author = "Tomohiro Iguchi and Ryutaro Uchi and Sho Nambara and Tomoko Saito and Hisateru Komatsu and Hidenari Hirata and Masami Ueda and Shotaro Sakimura and Yuki Takano and Jyunji Kurashige and Yoshiaki Shinden and Hidetoshi Eguchi and Keishi Sugimachi and Yoshihiko Maehara and Koshi Mimori",
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T1 - A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer

AU - Iguchi, Tomohiro

AU - Uchi, Ryutaro

AU - Nambara, Sho

AU - Saito, Tomoko

AU - Komatsu, Hisateru

AU - Hirata, Hidenari

AU - Ueda, Masami

AU - Sakimura, Shotaro

AU - Takano, Yuki

AU - Kurashige, Jyunji

AU - Shinden, Yoshiaki

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Maehara, Yoshihiko

AU - Mimori, Koshi

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

AB - Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNAATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the highlncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hemato genous meta-stases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.

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