A mathematical design of vector vaccine against autoimmune disease

Shingo Iwami, Yasuhiro Takeuchi, Kentaro Iwamoto, Yoshimi Naruo, Masahiro Yasukawa

研究成果: Contribution to journalArticle査読

16 被引用数 (Scopus)

抄録

Viruses have been implicated in the initiation, progression, and exacerbation of several human autoimmune diseases. Evidence also exists that viruses can protect against autoimmune disease. Several proposed mechanisms explain the viral effects. One mechanism is "molecular mimicry" which represents a shared immunologic epitope with a microbe and the host. We consider, using a simple mathematical model, whether and how a viral infection with molecular mimicry can be beneficial or detrimental for autoimmune disease. Furthermore, we consider the possibility of development of a vector therapeutic vaccine that can relieve autoimmune disease symptoms. Our findings demonstrate that vaccine therapy success necessitates (i) appropriate immune response function, (ii) appropriate affinities with self and non-self antigen, and (iii) a replicative vector vaccine. Moreover, the model shows that the viral infection can cause autoimmune relapses.

本文言語英語
ページ(範囲)382-392
ページ数11
ジャーナルJournal of Theoretical Biology
256
3
DOI
出版ステータス出版済み - 2 7 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 統計学および確率
  • モデリングとシミュレーション
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)
  • 農業および生物科学(全般)
  • 応用数学

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