A metabolomic approach to lung cancer

Suya Hori, Shin Nishiumi, Kazuyuki Kobayashi, Masakazu Shinohara, Yukihisa Hatakeyama, Yoshikazu Kotani, Naoya Hatano, Yoshimasa Maniwa, Wataru Nishio, Takeshi Bamba, Eiichiro Fukusaki, Takeshi Azuma, Tadaomi Takenawa, Yoshihiro Nishimura, Masaru Yoshida

研究成果: Contribution to journalArticle査読

138 被引用数 (Scopus)

抄録

Lung cancer is one of the most common cancers in the world, but no good clinical markers that can be used to diagnose the disease at an early stage and predict its prognosis have been found. Therefore, the discovery of novel clinical markers is required. In this study, metabolomic analysis of lung cancer patients was performed using gas chromatography mass spectrometry. Serum samples from 29 healthy volunteers and 33 lung cancer patients with adenocarcinoma (n= 12), squamous cell carcinoma (n= 11), or small cell carcinoma (n= 10) ranging from stage I to stage IV disease and lung tissue samples from 7 lung cancer patients including the tumor tissue and its surrounding normal tissue were used. A total of 58 metabolites (57 individual metabolites) were detected in serum, and 71 metabolites were detected in the lung tissue. The levels of 23 of the 58 serum metabolites were significantly changed in all lung cancer patients compared with healthy volunteers, and the levels of 48 of the 71 metabolites were significantly changed in the tumor tissue compared with the non-tumor tissue. Partial least squares discriminant analysis, which is a form of multiple classification analysis, was performed using the serum sample data, and metabolites that had characteristic alterations in each histological subtype and disease stage were determined. Our results demonstrate that changes in metabolite pattern are useful for assessing the clinical characteristics of lung cancer. Our results will hopefully lead to the establishment of novel diagnostic tools.

本文言語英語
ページ(範囲)284-292
ページ数9
ジャーナルLung Cancer
74
2
DOI
出版ステータス出版済み - 11 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 呼吸器内科
  • 癌研究

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