A method for comparing circular genomes from gene locations: Application to mitochondrial genomes

Katsuhisa Horimoto, Mikita Suyama, Hiroyuki Toh, Kentaro Mori, Jinya Otsuka

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Motivation: Data on the entire structures of organelle and bacterial genomes, most of which are known to be circular, have accumulated at a rapid pace. This information enables us to utilize the locations of homologous gene pairs for measuring the dissimilarity between complete genomic structures. Results: A macroscopic distance is presented for comparing circular genomes from their overall structures, on the basis of the locations of two pairs of homologous genes on the compared genomes. The novel aspect of our method is that the comparison between the genomes automatically reveals a relationship based on the information on all gene locations, by incorporating the mobility of each gene, which includes not only the gene order, but also the relative location between gene pairs. The plausibility of the newly defined distances is evaluated by means of 44 mitochondrial genomes. The genome distance shows high performance for quantitatively describing the differences between the gene organizations of the genomes. Availability: Since the programs implementing these calculations require well-arranged gene organization data, they have not been released yet. However, one of the authors will analyse circular genomes upon request. Data on the gene organizations may be submitted electronically to the address below. Contact: horimoto@@@ged.saga-med.ac.jp.

本文言語英語
ページ(範囲)789-802
ページ数14
ジャーナルBioinformatics
14
9
DOI
出版ステータス出版済み - 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 統計学および確率
  • 生化学
  • 分子生物学
  • コンピュータ サイエンスの応用
  • 計算理論と計算数学
  • 計算数学

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