A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: An association with a short tandem repeat and a hypermethylated region

Hideo Shibata, Yoshika Yoda, Reiko Kato, Takayuki Ueda, Mamoru Kamiya, Noriko Hiraiwa, Atsushi Yoshiki, Christoph Plass, R. Scott Pearsall, William A. Held, Masami Muramatsu, Hiroyuki Sasaki, Moriaki Kusakabe, Yoshihide Hayashizaki

研究成果: Contribution to journalArticle査読

33 被引用数 (Scopus)

抄録

We identified a sperm-specific methylation imprint mark (Site II) associated with a short tandem repeat sequence and a site/region methylated in both gametes (Site I) in the Grf1 locus on mouse chromosome 9, which shared a common feature with the U2afbp-rs gene. Sites or regions of gamete- specific methylation in imprinted genes are strong candidates for carrying information regarding the parental origin of alleles. The gamete-specific methylation pattern of Sites I and II was conserved after fertilization, but attained the somatic cell pattern by the blastocyst stage. In primordial germ cells, Site I was methylated, but Site II was unmethylated in both male and female embryos, suggesting that the sperm-specific methylation imprint mark in Site II was established during spermatogenesis. These common features in methylation imprint regions may be a clue to identifying regions carrying primary information for the imprinting regulation.

本文言語英語
ページ(範囲)30-37
ページ数8
ジャーナルGenomics
49
1
DOI
出版ステータス出版済み - 4 1 1998

All Science Journal Classification (ASJC) codes

  • Genetics

フィンガープリント 「A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: An association with a short tandem repeat and a hypermethylated region」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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