A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells

Takashi Katayama, Shintaro Kinugawa, Shingo Takada, Takaaki Furihata, A. Fukushima, Takashi Yokota, Toshihisa Anzai, Mitsue Hibino, Hideyoshi Harashima, Yuma Yamada

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

Mitochondrial function is reduced in skeletal muscles of many patients with systemic diseases and it is difficult to deliver medicinal substances to mitochondria in such tissue. In this study, we report on attempts to develop liposome-based carriers for mitochondrial delivery using mouse myoblasts (C2C12) by varying the lipid composition of the carriers. We found that a liposome that contains an optimal lipid modified with the KALA peptide (a cellular uptake and mitochondrial targeting device) was the most effective nanocarrier for achieving mitochondrial delivery in C2C12 cells. We also report on successful mitochondrial transgene expression using the carriers encapsulating a mitochondrial DNA vector as we previously reported.

本文言語英語
ページ(範囲)66-72
ページ数7
ジャーナルMitochondrion
49
DOI
出版ステータス出版済み - 11 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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