A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia

Toshiharu Matsuura, Kenichi Kohashi, Yusuke Yanagi, Isamu Saeki, Makoto Hayashida, Shinichi Aishima, Yoshinao Oda, Tomoaki Taguchi

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Background: In liver transplantation (LT) for adult biliary atresia (BA), we often encounter a cirrhotic deformation of the native liver. We aimed to investigate a morphological study of the removed livers and the patient's clinical status. Methods: We examined 8 BA patients who had undergone LT in adulthood at our hospital. The presence of hypertrophic or atrophic areas of the removed liver was recorded macroscopically. We graded the microscopic findings in the porta hepatis area, a hypertrophic area, and an atrophic area, respectively. Moreover, we investigated the relationship between these morphological findings and the pre-transplant clinical status (MELD score). Results: Macroscopically, a hypertrophic area existed in central liver in all cases (8/8 cases), while an atrophic area was existed in peripheral liver (7/8 cases). Microscopically, an atrophic area was the most severely impaired, while the porta hepatis and hypertrophic area were relatively intact. The pathological score in a compensatory hypertrophic area was strongly correlated with the MELD score. Conclusions: This study suggests that the partial shrinking is not uncommon in BA cirrhotic liver. It may be due to the imbalance of bile drainage by the different segment. The patient's pre-transplant status depends on the compensatory hypertrophic liver.

本文言語英語
ページ(範囲)1171-1175
ページ数5
ジャーナルPediatric surgery international
28
12
DOI
出版ステータス出版済み - 12 2012

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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