A multi-institutional analysis of prospective studies of carbon ion radiotherapy for prostate cancer: A report from the Japan Carbon ion Radiation Oncology Study Group (J-CROS)

Takuma Nomiya, Hiroshi Tsuji, Hidemasa Kawamura, Tatsuya Ohno, Shingo Toyama, Yoshiyuki Shioyama, Yuko Nakayama, Kenji Nemoto, Hirohiko Tsujii, Tadashi Kamada

研究成果: ジャーナルへの寄稿学術誌査読

48 被引用数 (Scopus)

抄録

Background and purpose A multi-institutional observational study (J-CROS1501PR) has been carried out to analyze outcomes of carbon-ion radiotherapy (CIRT) for patients with prostate cancer. Patients and methods Data of the patients enrolled in prospective studies of following 3 CIRT institutions were analyzed: National Institute of Radiological Sciences (NIRS; Chiba, Japan), Gunma University Heavy Ion Medical Center (GHMC; Gunma, Japan), and Ion Beam Therapy Center, SAGA HIMAT Foundation (HIMAT; Saga, Japan). Endpoints of the clinical trial are biochemical recurrence-free survival (bRFS), overall survival (OS), cause-specific survival (CSS), local control rate (LCR), and acute/late adverse effects. Results A total of 2157 patients’ data were collected from NIRS (n = 1432), GHMC (n = 515), and HIMAT (n = 210). The number of patients in low-risk, intermediate-risk, and high-risk groups was 263 (12%), 679 (31%), and 1215 (56%), respectively. The five-year bRFS in low-risk, intermediate-risk, and high-risk patients was 92%, 89%, and 92%, respectively. The five-year CSS in low-risk, intermediate-risk, and high-risk patients was 100%, 100%, and 99%, respectively. The incidence of grade 2 late GU/GI toxicities was 4.6% and 0.4%, respectively, and the incidence of ⩾G3 toxicities were 0%. Conclusions Favorable overall outcomes of CIRT for prostate cancer were suggested by the analysis of the first multi-institutional data.

本文言語英語
ページ(範囲)288-293
ページ数6
ジャーナルRadiotherapy and Oncology
121
2
DOI
出版ステータス出版済み - 11月 1 2016

!!!All Science Journal Classification (ASJC) codes

  • 血液学
  • 腫瘍学
  • 放射線学、核医学およびイメージング

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