A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans

Hitoshi Miyakawa, Kenji Toyota, Ikumi Hirakawa, Yukiko Ogino, Shinichi Miyagawa, Shigeto Oda, Norihisa Tatarazako, Toru Miura, John K. Colbourne, Taisen Iguchi

研究成果: ジャーナルへの寄稿記事

58 引用 (Scopus)

抄録

Juvenile hormone is an essential regulator of major developmental and life history events in arthropods. Most of the insects use juvenile hormone III as the innate juvenile hormone ligand. By contrast, crustaceans use methyl farnesoate. Despite this difference that is tied to their deep evolutionary divergence, the process of this ligand transition is unknown. Here we show that a single amino-acid substitution in the receptor Methoprene-tolerant has an important role during evolution of the arthropod juvenile hormone pathway. Microcrustacea Daphnia pulex and D. magna share a juvenile hormone signal transduction pathway with insects, involving Methoprene-tolerant and steroid receptor coactivator proteins that form a heterodimer in response to various juvenoids. Juvenile hormone-binding pockets of the orthologous genes differ by only two amino acids, yet a single substitution within Daphnia Met enhances the receptor's responsiveness to juvenile hormone III. These results indicate that this mutation within an ancestral insect lineage contributed to the evolution of a juvenile hormone III receptor system.

元の言語英語
記事番号1856
ジャーナルNature communications
4
DOI
出版物ステータス出版済み - 6 12 2013

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Methoprene
Juvenile Hormones
insects
hormones
mutations
Insects
Mutation
Daphnia
Arthropods
arthropods
Substitution reactions
Ligands
Amino Acids
Signal transduction
Steroid Receptors
amino acids
Amino Acid Substitution
substitutes
Signal Transduction
Genes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

これを引用

A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans. / Miyakawa, Hitoshi; Toyota, Kenji; Hirakawa, Ikumi; Ogino, Yukiko; Miyagawa, Shinichi; Oda, Shigeto; Tatarazako, Norihisa; Miura, Toru; Colbourne, John K.; Iguchi, Taisen.

:: Nature communications, 巻 4, 1856, 12.06.2013.

研究成果: ジャーナルへの寄稿記事

Miyakawa, H, Toyota, K, Hirakawa, I, Ogino, Y, Miyagawa, S, Oda, S, Tatarazako, N, Miura, T, Colbourne, JK & Iguchi, T 2013, 'A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans', Nature communications, 巻. 4, 1856. https://doi.org/10.1038/ncomms2868
Miyakawa, Hitoshi ; Toyota, Kenji ; Hirakawa, Ikumi ; Ogino, Yukiko ; Miyagawa, Shinichi ; Oda, Shigeto ; Tatarazako, Norihisa ; Miura, Toru ; Colbourne, John K. ; Iguchi, Taisen. / A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans. :: Nature communications. 2013 ; 巻 4.
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