A nano-sized gel-in-oil suspension for transcutaneous protein delivery

Safrina Dyah Hardiningtyas, Seiya Nagao, Emiko Yamamoto, Nana Shirakigawa, Rie Wakabayashi, Masahiro Goto, Hiroyuki Ijima, Noriho Kamiya

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.

本文言語英語
論文番号118495
ジャーナルInternational Journal of Pharmaceutics
567
DOI
出版ステータス出版済み - 8 15 2019

All Science Journal Classification (ASJC) codes

  • 薬科学

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