A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita; Masaharu Murata; Kana Abe; Sayoko Narahara; Jing Shu Piao; Jeong Hun Kang; Makoto Hashizume

doi:10.1039/c3cc44508a

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita, Masaharu Murata, Kana Abe, Sayoko Narahara, Jing Shu Piao, Jeong Hun Kang, Makoto Hashizume

研究成果: ジャーナルへの寄稿 › 記事

26 引用（Scopus）

抜粋

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

元の言語	英語
ページ（範囲）	7442-7444
ページ数	3
ジャーナル	Chemical Communications
巻	49
発行部数	67
DOI	https://doi.org/10.1039/c3cc44508a
出版物ステータス	出版済み - 7 25 2013

フィンガープリント

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

これを引用

Toita, R., Murata, M., Abe, K., Narahara, S., Piao, J. S., Kang, J. H., & Hashizume, M. (2013). A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells. Chemical Communications, 49(67), 7442-7444. https://doi.org/10.1039/c3cc44508a

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abstract = "Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.",

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AU - Piao, Jing Shu

AU - Kang, Jeong Hun

AU - Hashizume, Makoto

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文献にアクセス

10.1039/c3cc44508a