A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita; Masaharu Murata; Kana Abe; Sayoko Narahara; Jing Shu Piao; Jeong Hun Kang; Makoto Hashizume

doi:10.1039/c3cc44508a

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita, Masaharu Murata, Kana Abe, Sayoko Narahara, Jing Shu Piao, Jeong Hun Kang, Makoto Hashizume

先端医療医学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

37 被引用数 (Scopus)

抄録

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

本文言語	英語
ページ（範囲）	7442-7444
ページ数	3
ジャーナル	Chemical Communications
巻	49
号	67
DOI	https://doi.org/10.1039/c3cc44508a
出版ステータス	出版済み - 7月 25 2013

!!!All Science Journal Classification (ASJC) codes

触媒
電子材料、光学材料、および磁性材料
セラミックおよび複合材料
化学 (全般)
表面、皮膜および薄膜
金属および合金
材料化学

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abstract = "Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.",

author = "Riki Toita and Masaharu Murata and Kana Abe and Sayoko Narahara and Piao, {Jing Shu} and Kang, {Jeong Hun} and Makoto Hashizume",

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AU - Toita, Riki

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AU - Piao, Jing Shu

AU - Kang, Jeong Hun

AU - Hashizume, Makoto

PY - 2013/7/25

Y1 - 2013/7/25

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AB - Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

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A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

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!!!All Science Journal Classification (ASJC) codes

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