A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita; Masaharu Murata; Kana Abe; Sayoko Narahara; Jing Shu Piao; Jeong Hun Kang; Makoto Hashizume

doi:10.1039/c3cc44508a

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells

Riki Toita, Masaharu Murata, Kana Abe, Sayoko Narahara, Jing Shu Piao, Jeong Hun Kang, Makoto Hashizume

先端医療医学

研究成果: Contribution to journal › Article › 査読

30 被引用数 (Scopus)

抄録

Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage–doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.

本文言語	英語
ページ（範囲）	7442-7444
ページ数	3
ジャーナル	Chemical Communications
巻	49
号	67
DOI	https://doi.org/10.1039/c3cc44508a
出版ステータス	出版済み - 7 25 2013

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

文献へのアクセス

10.1039/c3cc44508a

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引用スタイル

A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells. / Toita, Riki; Murata, Masaharu; Abe, Kana; Narahara, Sayoko; Piao, Jing Shu; Kang, Jeong Hun; Hashizume, Makoto.

In: Chemical Communications, Vol. 49, No. 67, 25.07.2013, p. 7442-7444.

研究成果: Contribution to journal › Article › 査読

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