A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people

Hiroyuki Sawatari, Akiko Chishaki, Mari Nishizaka, Fumio Matsuoka, Chikara Yoshimura, Hiromi Kuroda, Anita Rahmawati, Nobuko Hashiguchi, Mami Miyazono, Junji Ono, Tomoko Ohkusa, Shin Ichi Ando

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

Objective It is well known that people with Down’s syndrome (DS) frequently complicate with congenital heart diseases (CHDs). Patients with heart diseases often have sleep-disordered breathing as a co-morbidity (SDB) which worsens the heart diseases. However, the relationship between SDB and CHDs in DS people has not yet been fully elucidated. The aim of this study was to establish the association between SDB and CHDs in DS people using data from a large nationwide questionnaire survey in Japan. Methods We conducted a cross-sectional questionnaire survey of a randomly selected sample of 2,000 DS people and their caregivers throughout Japan to examine the associations between observed signs of SDB and CHDs in DS people. The questionnaire included the presence of SDB symptoms (snoring, apnea, arousal, nocturia, and napping) and CHDs (the presence and types of CHDs). Results Of the 1,222 replies received from the caregivers, 650 reported complications of some type of CHDs. The observed apnea tended to be higher among DS people with CHDs than those without CHDs (OR=1.28, 95% CI=0.97-1.70, p=0.09). DS people with tetralogy of Fallot reported significantly more frequent apnea than those without CHDs (OR=3.10, 95% CI=1.36-7.05, p<0.01). Conclusion SDB prevailed among DS people with severe CHDs, such as tetralogy of Fallot. Careful attention to the signs of SDB in such patients may lead to earlier clinical intervention removing the vicious cycle between SDB and CHDs.

本文言語英語
ページ(範囲)1003-1008
ページ数6
ジャーナルInternal Medicine
54
9
DOI
出版ステータス出版済み - 2015

All Science Journal Classification (ASJC) codes

  • 内科学

フィンガープリント

「A nationwide cross-sectional study on congenital heart diseases and symptoms of sleep-disordered breathing among japanese down’s syndrome people」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル