A nationwide questionnaire survey on the prevalence of ankylosing spondylitis and non-radiographic axial spondyloarthritis in Japan

Yuri Matsubara, Yosikazu Nakamura, Naoto Tamura, Hideto Kameda, Kotaro Otomo, Mitsumasa Kishimoto, Yuho Kadono, Shigeyoshi Tsuji, Tatsuya Atsumi, Hiroaki Matsuno, Michiaki Takagi, Shigeto Kobayashi, Keishi Fujio, Norihiro Nishimoto, Nami Okamoto, Ayako Nakajima, Kiyoshi Matsui, Masahiro Yamamura, Yasuharu Nakashima, Atsushi KawakamiMasaaki Mori, Tetsuya Tomita

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

OBJECTIVE: This nationwide study aimed to reveal the prevalence of ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis (nr-ax SpA), and the positivity rate of human leukocyte antigen (HLA) among such patients in Japan. METHODS: The first survey was conducted in 2221 randomly selected facilities (26.3%) in September 2018, where the patients with AS/nr-ax SpA were taken care of from January to December 2017. We estimated the total number of these patients using response and extraction rates. A second survey was conducted in 117 facilities (49.8%) to assess for HLA-B27 positivity rate and clinical features. RESULTS: The estimated total numbers of the patients with AS and nr-ax SpA were 3200 (95% confidence interval [CI]: 2400-3900) and 800 (530-1100), suggesting that the prevalence values of AS and nr-ax SpA in general population were 2.6/100,000 (0.0026%) and 0.6/100,000 (0.0006%), respectively. Although 55.5% (76/137) of patients with AS were HLA-B27-positive, those whose age of onset was estimated to be over 50 years tended to undergo less HLA-B27 testing. CONCLUSION: This study revealed the lower prevalence of AS/nr-ax SpA in Japan, compared to those in other countries. Further studies are required to reveal the association of HLA-B27 with the clinical features.

本文言語英語
ページ(範囲)960-967
ページ数8
ジャーナルModern Rheumatology
32
5
DOI
出版ステータス出版済み - 8月 20 2022

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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