A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan

Yuki Inagaki, Yukio Oshiro, Tomohiro Tanaka, Tomoharu Yoshizumi, Hideaki Okajima, Kohei Ishiyama, Chikashi Nakanishi, Masaaki Hidaka, Hiroshi Wada, Taizo Hibi, Kosei Takagi, Masaki Honda, Kaori Kuramitsu, Hideaki Tanaka, Taiji Tohyama, Toshihiko Ikegami, Satoru Imura, Tsuyoshi Shimamura, Yoshimi Nakayama, Taizen UrahashiKazumasa Yamagishi, Hiroshi Ohnishi, Shigeo Nagashima, Masaharu Takahashi, Ken Shirabe, Norihiro Kokudo, Hiroaki Okamoto, Nobuhiro Ohkohchi

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

Background: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. Methods: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. Findings: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9% (54/1893), 0.05% (1/1893) and 0% (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12%) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. Interpretation: The prevalence of HEV antibodies in liver transplant recipients was 2.9%, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation.

元の言語英語
ページ(範囲)1607-1612
ページ数6
ジャーナルEBioMedicine
2
発行部数11
DOI
出版物ステータス出版済み - 11 1 2015

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Hepatitis E
Hepatitis E virus
Transplants
Virus Diseases
Chronic Hepatitis
Viruses
Liver
Japan
Blood
RNA
Liver Transplantation
Immunoglobulin A
Immunoglobulin M
Transplant Recipients
Surveys and Questionnaires
Hepatitis Antibodies
Immunoglobulin G
Torque teno virus
Perioperative Period
Antibodies

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan. / Inagaki, Yuki; Oshiro, Yukio; Tanaka, Tomohiro; Yoshizumi, Tomoharu; Okajima, Hideaki; Ishiyama, Kohei; Nakanishi, Chikashi; Hidaka, Masaaki; Wada, Hiroshi; Hibi, Taizo; Takagi, Kosei; Honda, Masaki; Kuramitsu, Kaori; Tanaka, Hideaki; Tohyama, Taiji; Ikegami, Toshihiko; Imura, Satoru; Shimamura, Tsuyoshi; Nakayama, Yoshimi; Urahashi, Taizen; Yamagishi, Kazumasa; Ohnishi, Hiroshi; Nagashima, Shigeo; Takahashi, Masaharu; Shirabe, Ken; Kokudo, Norihiro; Okamoto, Hiroaki; Ohkohchi, Nobuhiro.

:: EBioMedicine, 巻 2, 番号 11, 01.11.2015, p. 1607-1612.

研究成果: ジャーナルへの寄稿記事

Inagaki, Y, Oshiro, Y, Tanaka, T, Yoshizumi, T, Okajima, H, Ishiyama, K, Nakanishi, C, Hidaka, M, Wada, H, Hibi, T, Takagi, K, Honda, M, Kuramitsu, K, Tanaka, H, Tohyama, T, Ikegami, T, Imura, S, Shimamura, T, Nakayama, Y, Urahashi, T, Yamagishi, K, Ohnishi, H, Nagashima, S, Takahashi, M, Shirabe, K, Kokudo, N, Okamoto, H & Ohkohchi, N 2015, 'A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan', EBioMedicine, 巻. 2, 番号 11, pp. 1607-1612. https://doi.org/10.1016/j.ebiom.2015.09.030
Inagaki, Yuki ; Oshiro, Yukio ; Tanaka, Tomohiro ; Yoshizumi, Tomoharu ; Okajima, Hideaki ; Ishiyama, Kohei ; Nakanishi, Chikashi ; Hidaka, Masaaki ; Wada, Hiroshi ; Hibi, Taizo ; Takagi, Kosei ; Honda, Masaki ; Kuramitsu, Kaori ; Tanaka, Hideaki ; Tohyama, Taiji ; Ikegami, Toshihiko ; Imura, Satoru ; Shimamura, Tsuyoshi ; Nakayama, Yoshimi ; Urahashi, Taizen ; Yamagishi, Kazumasa ; Ohnishi, Hiroshi ; Nagashima, Shigeo ; Takahashi, Masaharu ; Shirabe, Ken ; Kokudo, Norihiro ; Okamoto, Hiroaki ; Ohkohchi, Nobuhiro. / A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan. :: EBioMedicine. 2015 ; 巻 2, 番号 11. pp. 1607-1612.
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title = "A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan",
abstract = "Background: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. Methods: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. Findings: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9{\%} (54/1893), 0.05{\%} (1/1893) and 0{\%} (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12{\%}) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. Interpretation: The prevalence of HEV antibodies in liver transplant recipients was 2.9{\%}, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation.",
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T1 - A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan

AU - Inagaki, Yuki

AU - Oshiro, Yukio

AU - Tanaka, Tomohiro

AU - Yoshizumi, Tomoharu

AU - Okajima, Hideaki

AU - Ishiyama, Kohei

AU - Nakanishi, Chikashi

AU - Hidaka, Masaaki

AU - Wada, Hiroshi

AU - Hibi, Taizo

AU - Takagi, Kosei

AU - Honda, Masaki

AU - Kuramitsu, Kaori

AU - Tanaka, Hideaki

AU - Tohyama, Taiji

AU - Ikegami, Toshihiko

AU - Imura, Satoru

AU - Shimamura, Tsuyoshi

AU - Nakayama, Yoshimi

AU - Urahashi, Taizen

AU - Yamagishi, Kazumasa

AU - Ohnishi, Hiroshi

AU - Nagashima, Shigeo

AU - Takahashi, Masaharu

AU - Shirabe, Ken

AU - Kokudo, Norihiro

AU - Okamoto, Hiroaki

AU - Ohkohchi, Nobuhiro

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. Methods: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. Findings: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9% (54/1893), 0.05% (1/1893) and 0% (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12%) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. Interpretation: The prevalence of HEV antibodies in liver transplant recipients was 2.9%, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation.

AB - Background: Recently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients. Methods: A total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), IgM and IgA classes of anti-HEV antibodies, and HEV RNA in serum. Findings: The prevalence of anti-HEV IgG, IgM and IgA class antibodies was 2.9% (54/1893), 0.05% (1/1893) and 0% (0/1893), respectively. Of 1651 patients tested for HEV RNA, two patients (0.12%) were found to be positive and developed chronic infection after liver transplantation. In both cases, HEV RNA was also detected in one of the blood products transfused at the perioperative period. Analysis of the HEV genomes revealed that the HEV isolates obtained from the recipients and the transfused blood products were identical in both cases, indicating transfusion-transmitted HEV infection. Interpretation: The prevalence of HEV antibodies in liver transplant recipients was 2.9%, which is low compared with the healthy population in Japan and with organ transplant recipients in European countries; however, the present study found, for the first time, two Japanese patients with chronic HEV infection that was acquired via blood transfusion during or after liver transplantation.

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